GEMIN4 and ZNF35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GEMIN4	ZNF35
Description		gem nuclear organelle associated protein 4	zinc finger protein 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Cellular Response To Retinoic Acid
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Bipolar disorder ( 31043756)
Interacting Genes		57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35	32 interacting genes: APP ATPAF2 CCDC136 CDC5L CDR2 CDR2L CEP70 CREB1 CWF19L2 EEF2KMT EXOC8 FSD2 GEMIN4 GOLGA2 GOLGA6L9 GRIPAP1 HOMER3 HOMEZ HOOK1 HOOK2 LZTS1 MCC MTUS2 MYD88 NDEL1 PIBF1 PICK1 PNMA1 PRKAR1B TRAF2 YJU2B ZBTB8A
Entrez ID		50628	7584
HPRD ID		07370	01920
Ensembl ID		ENSG00000179409	ENSG00000169981
Uniprot IDs		I3L2C7 P57678 Q8WUM5 Q9HC39	P13682
PDB IDs
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process	Identical Protein Binding Positive Regulation Of Long-term Synaptic Potentiation Cytoskeleton-dependent Intracellular Transport Regulation Of Synaptic Plasticity FHF Complex Regulation Of Long-term Synaptic Potentiation Microtubule Binding Protein Localization To Perinuclear Region Of Cytoplasm Post-mRNA Release Spliceosomal Complex Centrosome Modulation Of Chemical Synaptic Transmission Vesicle Organization HOPS Complex Microtubule Protein Binding Endosome Organization Microtubule-based Process
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