AGTR1 and GRK5

Number of citations of the paper that reports this interaction (PubMedID 9211925)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		AGTR1	GRK5
Description		angiotensin II receptor type 1	G protein-coupled receptor kinase 5
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	G alpha (q) signalling events G alpha (s) signalling events
Drugs		Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases		Renal tubular dysgenesis
GWAS		Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)	Appendicular lean mass ( 33097823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31676865 31420334) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		185	2869
HPRD ID		00107	02926
Ensembl ID		ENSG00000144891	ENSG00000198873
Uniprot IDs		A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5	P34947
PDB IDs		4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2	4TNB 4TND 6PJX 8UAP 8UAQ 9BRE 9BRG 9BRH 9BRI 9BRJ
Enriched GO Terms of Interacting Partners?		Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway	Regulation Of Vasoconstriction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Circulation Positive Regulation Of Vasoconstriction G Protein-coupled Receptor Activity Regulation Of System Process G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Circulatory System Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cytosolic Calcium Ion Concentration System Process Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction Regulation Of Transport Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of Muscle Contraction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Blood Pressure Vasopressin Receptor Activity Regulation Of Cell Communication Cuprous Ion Binding Presynaptic Endocytosis Regulation Of Muscle System Process Smooth Muscle Contraction Regulation Of Signaling Regulation Of Small Molecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Plasma Membrane Regulation Of Secretion Vesicle-mediated Transport In Synapse Endocytosis Sperm Ejaculation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Endosome Synaptic Vesicle Endocytosis Signal Transduction Membrane Chemical Synaptic Transmission Sperm Midpiece Positive Regulation Of Small Molecule Metabolic Process Regulation Of Secretion By Cell Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Axon Terminus Aggressive Behavior
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?