AGTR1 and SLC16A1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		AGTR1	SLC16A1
Description		angiotensin II receptor type 1	solute carrier family 16 member 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Centrosome Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Synapse Extracellular Exosome
	Molecular Function	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Mevalonate Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Symporter Activity Solute:proton Symporter Activity Secondary Active Monocarboxylate Transmembrane Transporter Activity Lactate:proton Symporter Activity Transmembrane Transporter Activity Identical Protein Binding Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process	Lipid Metabolic Process Centrosome Cycle Monocarboxylic Acid Transport Mevalonate Transport Response To Food Lactate Transmembrane Transport Plasma Membrane Lactate Transport Glucose Homeostasis Pyruvate Catabolic Process Regulation Of Insulin Secretion Behavioral Response To Nutrient Transmembrane Transport Succinate Transmembrane Transport Transport Across Blood-brain Barrier Pyruvate Transmembrane Transport Proton Transmembrane Transport Carboxylic Acid Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Basigin interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME
Drugs		Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Pyruvic acid Mersalyl
Diseases		Renal tubular dysgenesis
GWAS		Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)	Macular thickness ( 30535121) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278)
Interacting Genes		77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ	3 interacting genes: AGTR1 BSG CRBN
Entrez ID		185	6566
HPRD ID		00107	02816
Ensembl ID		ENSG00000144891	ENSG00000155380
Uniprot IDs		A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5	B4DKS0 P53985
PDB IDs		4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2	6LYY 6LZ0 7CKO 7CKR 7DA5 7YR5
Enriched GO Terms of Interacting Partners?		Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway	Cell Chemotaxis Angiotensin Type I Receptor Activity Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Matrix Metallopeptidase Secretion Regulation Of Transport Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Locomotion Chemotaxis Regulation Of Renal Sodium Excretion Response To Mercury Ion Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Matrix Metallopeptidase Secretion Endothelial Tube Morphogenesis Positive Regulation Of Viral Entry Into Host Cell Cul4A-RING E3 Ubiquitin Ligase Complex Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Dendrite Self-avoidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Secretion By Cell Neural Retina Development Regulation Of Secretion Regulation Of Viral Entry Into Host Cell D-mannose Binding Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Viral Life Cycle Decidualization Acrosomal Membrane Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Derived Foam Cell Differentiation Exploration Behavior Plasma Lipoprotein Particle Remodeling Cell-cell Adhesion Mediator Activity Protein-containing Complex Remodeling Photoreceptor Cell Maintenance Positive Regulation Of Steroid Metabolic Process Cell Migration Regulation Of Systemic Arterial Blood Pressure Embryo Implantation Neuron Recognition
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