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AGTR1 and HRAS
Number of citations of the paper that reports this interaction (PubMedID
8753867
)
51
Data Source:
HPRD
(in vitro, in vivo)
AGTR1
HRAS
Description
angiotensin II receptor type 1
HRas proto-oncogene, GTPase
Image
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
GTPase Complex
Molecular Function
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
GDP Binding
Protein-membrane Adaptor Activity
Phospholipase C Activator Activity
Biological Process
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Symbiont Entry Into Host Cell
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Positive Regulation Of Cholesterol Metabolic Process
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Endocytosis
Chemotaxis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Schwann Cell Development
Positive Regulation Of Cell Migration
Positive Regulation Of Type II Interferon Production
Regulation Of Actin Cytoskeleton Organization
T-helper 1 Type Immune Response
Regulation Of Cell Population Proliferation
Myelination
Defense Response To Protozoan
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Epithelial Cell Proliferation
T Cell Receptor Signaling Pathway
Neuron Apoptotic Process
Regulation Of Cell Cycle
Adipose Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Gamma Radiation
Positive Regulation Of Wound Healing
Positive Regulation Of Protein Targeting To Membrane
Cellular Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Positive Regulation Of Ruffle Assembly
Positive Regulation Of MiRNA Metabolic Process
Pathways
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by RAS GAP mutants
Signaling by RAS GTPase mutants
Drugs
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Hexane-1,6-Diol
Trifluoroethanol
Guanosine-5'-Triphosphate
Guanosine-5'-Diphosphate
N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Ursolic acid
Diseases
Renal tubular dysgenesis
Penile cancer
Cervical cancer
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Hepatocellular carcinoma
Thyroid cancer
Squamous cell carcinoma
Bladder cancer
GWAS
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Interacting Genes
77 interacting genes:
ABI3
ACE2
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
148 interacting genes:
ABR
ACTG1
AFDN
AGTR1
ANAPC1
ANKRD11
ANKRD16
ANKRD23
ANKRD34B
APBB1IP
ARAF
ARFGAP1
ARHGAP10
ARHGAP29
ARHGEF1
ARHGEF18
BCL2
BLID
BMPR1A
BRAF
BRAP
BUB1
CAV1
CDC123
CDC25A
CDC25C
CDH1
CDKN2A
CTNNA1
CXCL1
DEAF1
DGKE
DGKZ
DPP9
EIF3L
ERBB2
FBXW7
FNTA
FNTB
FYN
GPSM2
GPSM3
GRB2
GREB1
GRIN1
GRIN2D
HECTD1
HSPA12A
HSPA1L
ICMT
IKZF3
IL1RL1
IL24
IL3
INSR
IRAK1
IRAK2
ITGB3
ITSN1
KRAS
KRT17
KRT18
LGALS1
LZTR1
MAP2K1
MAP2K6
MAP3K6
MAPK10
MAPK8
MLH3
MSH2
MSH6
MTOR
MUTYH
NEDD4
NF1
NRAS
PDE4D
PDE6D
PDGFB
PDGFRL
PI4K2A
PIK3CA
PIK3CD
PIK3CG
PIK3R1
PLA2G4B
PLAAT4
PLCE1
PLCH2
PRKCI
PRKCZ
PRSS50
PTPRJ
QPCT
RAB5C
RABAC1
RABGEF1
RAF1
RALGDS
RAP1B
RAP1GDS1
RAPGEF1
RASA1
RASA2
RASA4
RASGRF1
RASGRP1
RASGRP4
RASIP1
RASSF1
RASSF2
RASSF5
RGL1
RGL2
RGL4
RGS12
RHOD
RIN1
RIT2
RNF115
RSPO3
SHOC2
SMAD4
SNRPE
SNX14
SNX17
SOS1
SOS2
SRC
STK11
STK38
TIAM1
TLR2
TLR6
TLR9
TP73
TTC1
TTC21A
TTC28
UBE3B
UBE4B
USP29
USP42
VAV1
ZBTB10
ZBTB12
ZDHHC9
Entrez ID
185
3265
HPRD ID
00107
01813
Ensembl ID
ENSG00000144891
ENSG00000174775
Uniprot IDs
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
P01112
X5D945
PDB IDs
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
121P
1AA9
1AGP
1BKD
1CLU
1CRP
1CRQ
1CRR
1CTQ
1GNP
1GNQ
1GNR
1HE8
1IAQ
1IOZ
1JAH
1JAI
1K8R
1LF0
1LF5
1LFD
1NVU
1NVV
1NVW
1NVX
1P2S
1P2T
1P2U
1P2V
1PLJ
1PLK
1PLL
1Q21
1QRA
1RVD
1WQ1
1XCM
1XD2
1XJ0
1ZVQ
1ZW6
221P
2C5L
2CE2
2CL0
2CL6
2CL7
2CLC
2CLD
2EVW
2LCF
2LWI
2N42
2N46
2Q21
2QUZ
2RGA
2RGB
2RGC
2RGD
2RGE
2RGG
2UZI
2VH5
2X1V
3DDC
3I3S
3K8Y
3K9L
3K9N
3KKM
3KKN
3KUD
3L8Y
3L8Z
3LBH
3LBI
3LBN
3LO5
3OIU
3OIV
3OIW
3RRY
3RRZ
3RS0
3RS2
3RS3
3RS4
3RS5
3RS7
3RSL
3RSO
3TGP
421P
4DLR
4DLS
4DLT
4DLU
4DLV
4DLW
4DLX
4DLY
4DLZ
4DST
4DSU
4EFL
4EFM
4EFN
4G0N
4G3X
4K81
4L9S
4L9W
4NYI
4NYJ
4NYM
4Q21
4RSG
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
4XVQ
4XVR
521P
5B2Z
5B30
5E95
5P21
5VBE
5VBZ
5WDO
5WDP
5WDQ
5WFO
5WFP
5WFQ
5WFR
5WPL
5X9S
5ZC6
621P
6AMB
6AXG
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6DZH
6E6C
6E6P
6MQT
6NTC
6NTD
6Q21
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6ZJ0
6ZL3
721P
7DPH
7DPJ
7JHP
7JIF
7JIG
7JIH
7JII
7L0F
7L0G
7OG9
7OGA
7OGB
7OGC
7OGD
7OGE
7OGF
7TAM
7VV8
7VV9
7VVG
821P
8BE6
8BE7
8BE8
8BE9
8BEA
8BOS
8BWG
8CNJ
8CNN
8ELK
8ELR
8ELS
8ELT
8ELU
8ELV
8ELW
8ELX
8ELY
8ELZ
8EM0
8FG3
8FG4
8OSM
8OSN
8OSO
8TBG
8TLR
8WWC
Enriched GO Terms of Interacting Partners
?
Negative Adaptation Of Signaling Pathway
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Beta-adrenergic Receptor Kinase Activity
Regulation Of G Protein-coupled Receptor Signaling Pathway
Receptor Internalization
Type 1 Angiotensin Receptor Binding
G Protein-coupled Receptor Binding
G Protein-coupled Receptor Kinase Activity
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Receptor-mediated Endocytosis
Regulation Of Cell Communication
Regulation Of Signaling
Angiotensin Receptor Binding
Endocytic Vesicle Membrane
Membrane
Type II Interferon-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Regulation Of Biological Quality
Regulation Of Muscle System Process
Regulation Of Protein Modification Process
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Blood Circulation
Postsynaptic Density
Negative Regulation Of Signal Transduction
Establishment Of Protein Localization
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Endocytosis
Regulation Of MAPK Cascade
Regulation Of Vasoconstriction
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Positive Regulation Of Receptor Internalization
Regulation Of The Force Of Heart Contraction By Chemical Signal
Positive Regulation Of Gap Junction Assembly
Interferon-mediated Signaling Pathway
Plasma Membrane
Clathrin-coated Pit
Protein Transport
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Phosphorylation
Cytoplasm
ERBB Signaling Pathway
Import Into Cell
Negative Regulation Of Apoptotic Process
Tachykinin Receptor Signaling Pathway
Intracellular Signal Transduction
Signal Transduction
Intracellular Signaling Cassette
Ras Protein Signal Transduction
Regulation Of Intracellular Signal Transduction
Small GTPase-mediated Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Cytosol
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Guanyl-nucleotide Exchange Factor Activity
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Activation
Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
MAPK Cascade
Positive Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-activating Signaling Pathway
Cytoplasm
Positive Regulation Of MAPK Cascade
Regulation Of Cell Activation
Leukocyte Activation
Regulation Of Cellular Component Organization
Kinase Activity
Regulation Of Protein Serine/threonine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Adhesion
Protein Kinase Activity
Regulation Of Programmed Cell Death
Activation Of Immune Response
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Immune Response
Regulation Of Ras Protein Signal Transduction
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Defense Response
Plasma Membrane
Lymphocyte Activation
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Tagcloud (Intersection)
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