RPL3 and NDRG1

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		RPL3	NDRG1
Gene Name		ribosomal protein L3	N-myc downstream regulated 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Cellular Response To Interleukin-4	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		4 interactors: NDRG1 NUMB SIK1 STXBP3	64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		6122	10397
HPRD ID		16042	05586
Ensembl ID		ENSG00000100316	ENSG00000104419
Uniprot IDs		B3KS36 P39023 Q96QL0	Q8N959 Q92597
PDB IDs		3J3B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Polarized Epithelial Cell Differentiation Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of Anoikis Neuroblast Division In Subventricular Zone System Development Positive Regulation Of Spindle Checkpoint Neutrophil Degranulation Protein To Membrane Docking Neutrophil Activation Involved In Immune Response Positive Regulation Of Cell Cycle Checkpoint Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Gluconeogenesis Forebrain Neuroblast Division Leukocyte Activation Developmental Process Regulation Of Anoikis Regulation Of Triglyceride Biosynthetic Process Peripheral Nervous System Myelin Maintenance Signaling Negative Regulation Of Calcium Ion-dependent Exocytosis Nervous System Development Negative Regulation Of Protein Localization To Plasma Membrane Neutrophil Mediated Immunity Cell Communication Lateral Ventricle Development Neutrophil Activation Entrainment Of Circadian Clock By Photoperiod Regulation Of Spindle Checkpoint Somatic Stem Cell Division Photoperiodism Entrainment Of Circadian Clock Cell Activation Myelin Maintenance Negative Regulation Of Notch Signaling Pathway Mast Cell Activation Regulation Of Triglyceride Metabolic Process Brain Development Regulation Of Cell Cycle Checkpoint Negative Regulation Of Exocytosis Head Development Platelet Aggregation Stem Cell Division Leukocyte Degranulation Insulin Secretion Ventricular System Development Myelination In Peripheral Nervous System Organ Development Membrane Organization	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas pgk1 polysome pyk1 raising rp29 saccharomyces starvation stationary thi4 translatabilities translated translational	4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw
Tagcloud (Difference) ?		4a act1 apparatus carrying compete differing efficiencies enter entry exponential hsp12 hsp26 idea inert lacz leaders mrnas pgk1 polysome pyk1 raising rp29 saccharomyces starvation stationary thi4 translatabilities translated translational	4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw
Tagcloud (Intersection) ?