RPL3 and STXBP3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL3	STXBP3
Description		ribosomal protein L3	syntaxin binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Platelet Alpha Granule Specific Granule Phagocytic Vesicle Extracellular Exosome Tertiary Granule Presynapse
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Syntaxin-1 Binding Syntaxin Binding Protein-containing Complex Binding
	Biological Process	Cytoplasmic Translation Translation Cellular Response To Interleukin-4	Intracellular Glucose Homeostasis Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Response To Stress Immune Response Brain Development Protein Transport Vesicle-mediated Transport Protein To Membrane Docking Insulin Secretion Response To Insulin Neutrophil Degranulation Regulated Exocytosis Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of D-glucose Import Negative Regulation Of Transport Regulation Of Biological Quality Platelet Aggregation Cellular Response To Type II Interferon Presynaptic Dense Core Vesicle Exocytosis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Disinhibition of SNARE formation Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs		(S)-3-phenyllactic acid Omacetaxine mepesuccinate Anisomycin Puromycin Xanthinol
Diseases
GWAS		Crohn's disease ( 28067908) Factor VIII levels ( 30586737) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Ulcerative colitis ( 28067908) vWF levels ( 30586737)	Fat distribution (HIV) ( 21897333)
Interacting Genes		13 interacting genes: CREBBP DUX4 EXOSC8 ISG15 MTNR1A NDRG1 NUMB OGT RBFOX2 SIK1 STXBP3 SUMO2 TRAF6	15 interacting genes: DDX20 GEMIN2 GEMIN4 GEMIN5 PRKCA RPL3 SMN1 SNCA SNRPB SNRPD2 SNRPD3 SNTG1 STX4 STXBP2 VAMP2
Entrez ID		6122	6814
HPRD ID		16042	10517
Ensembl ID		ENSG00000100316	ENSG00000116266
Uniprot IDs		B3KS36 P39023 Q96QL0	O00186
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Rhythmic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Protein Tag Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Histone Acetyltransferase Complex Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Membrane Regulation Of Protein Ubiquitination Protein Modification Process Glutamatergic Synapse Regulation Of Post-translational Protein Modification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Gluconeogenesis Canonical NF-kappaB Signal Transduction Histone H3K18 Acetyltransferase Activity Chromatin DNA Binding Cytoplasm Negative Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Gene Expression Histone H3K27 Acetyltransferase Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Tertiary Granule Positive Regulation Of Type I Interferon Production Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Ubiquitination Protein O-acetylglucosaminyltransferase Activity Neuroblast Division In Subventricular Zone U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Melatonin Receptor Activity Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Oligomerization Negative Regulation Of CREB Transcription Factor Activity	SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SMN Complex Gemini Of Cajal Bodies Protein-RNA Complex Assembly RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Small Nuclear Ribonucleoprotein Complex MRNA Processing Protein-containing Complex Organization MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Cellular Component Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP SNARE Complex Assembly Methylosome RNA Processing Regulation Of Exocytosis Nuclear Body U1 SnRNP U5 SnRNP Cytosol U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Synaptic Vesicle Exocytosis Histone Pre-mRNA DCP Binding U4/U6 X U5 Tri-snRNP Complex RNA Metabolic Process U2-type Precatalytic Spliceosome PICln-Sm Protein Complex Long-term Synaptic Potentiation Spliceosomal Complex U7 SnRNP Neutrophil Degranulation SNARE Binding MRNA Splicing, Via Spliceosome Exocytosis RNA Methylation Positive Regulation Of Exocytosis Catalytic Step 2 Spliceosome Specific Granule Vesicle-mediated Transport In Synapse Response To Cytokine Regulation Of Vesicle-mediated Transport Response To Peptide
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