RPL3 and NUMB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL3	NUMB
Description		ribosomal protein L3	NUMB endocytic adaptor protein
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex	Cytoplasm Endosome Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Cytoplasmic Translation Translation Cellular Response To Interleukin-4	Nervous System Development Neuroblast Proliferation Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		(S)-3-phenyllactic acid Omacetaxine mepesuccinate Anisomycin Puromycin Xanthinol
Diseases
GWAS		Crohn's disease ( 28067908) Factor VIII levels ( 30586737) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Ulcerative colitis ( 28067908) vWF levels ( 30586737)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Hemoglobin ( 32888494) Macular thickness ( 30535121) Multisite chronic pain ( 31194737 33830993) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		13 interacting genes: CREBBP DUX4 EXOSC8 ISG15 MTNR1A NDRG1 NUMB OGT RBFOX2 SIK1 STXBP3 SUMO2 TRAF6	38 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IQGAP1 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 NRON OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2
Entrez ID		6122	8650
HPRD ID		16042	04767
Ensembl ID		ENSG00000100316	ENSG00000133961
Uniprot IDs		B3KS36 P39023 Q96QL0	P49757
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	5NJJ 5NJK
Enriched GO Terms of Interacting Partners?		Rhythmic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Protein Tag Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Histone Acetyltransferase Complex Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Membrane Regulation Of Protein Ubiquitination Protein Modification Process Glutamatergic Synapse Regulation Of Post-translational Protein Modification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Gluconeogenesis Canonical NF-kappaB Signal Transduction Histone H3K18 Acetyltransferase Activity Chromatin DNA Binding Cytoplasm Negative Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Gene Expression Histone H3K27 Acetyltransferase Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Tertiary Granule Positive Regulation Of Type I Interferon Production Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Ubiquitination Protein O-acetylglucosaminyltransferase Activity Neuroblast Division In Subventricular Zone U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Melatonin Receptor Activity Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Oligomerization Negative Regulation Of CREB Transcription Factor Activity	Diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Plasma Membrane Receptor Internalization Positive Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Apical Plasma Membrane Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Signaling Negative Regulation Of Programmed Cell Death Endocytosis Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Superoxide Metabolic Process Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death AP-2 Adaptor Complex Positive Regulation Of Metabolic Process Regulation Of Cell Communication Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Catabolic Process Extracellular Exosome Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transport Programmed Cell Death Cell Death Negative Regulation Of Insulin Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?