GNB4 and GNG3

Number of citations of the paper that reports this interaction (PMID 8636150)
15

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		GNB4	GNG3
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 4	guanine nucleotide binding protein (G protein), gamma 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	Signal Transducer Activity Protein Complex Binding	GTPase Activity Signal Transducer Activity Type 1 Angiotensin Receptor Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Substantia Nigra Development Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Activation Of MAPK Activity Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport GPCR ligand binding beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		17 interactors: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MTNR1A MTNR1B	5 interactors: GNB1 GNB2 GNB3 GNB4 GNB5
Entrez ID		59345	2785
HPRD ID		09973	12337
Ensembl ID			ENSG00000162188
Uniprot IDs		Q9HAV0	P63215
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Response To Peptide Hormone Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Oxidation-reduction Process Response To Stimulus Cellular Response To Organic Substance Response To Organic Substance Small Molecule Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Platelet Activation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Phototransduction Regulation Of CAMP Metabolic Process Detection Of Light Stimulus Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Body Fluid Levels Vesicle Fusion Wound Healing Cell Activation	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Regulation Of Rhodopsin Mediated Signaling Pathway Response To Hormone Rhodopsin Mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway Oxidation-reduction Process Phototransduction, Visible Light Detection Of Visible Light Synaptic Transmission Cellular Response To Light Stimulus Phototransduction Cellular Response To Organic Substance Detection Of Light Stimulus Cellular Response To Radiation Small Molecule Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell-cell Signaling Signal Transduction Response To Organic Substance Signaling Cell Communication Negative Regulation Of Voltage-gated Calcium Channel Activity Cardiac Muscle Cell Apoptotic Process Cell Surface Receptor Signaling Pathway Muscle Cell Apoptotic Process Cellular Response To Stimulus Response To Light Stimulus Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Radiation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Detection Of Stimulus
Tagcloud ?			1n9 angus asb3 backfat corticotropin crossbreeding dermatan desaturase dsel efemp1 epimerase fibulin hardy healthful heterosis linolenic marbling oleic overdominant palmitic parentage pltp sires slc27a1 slc27a2 solute wagyu wagyuxangus weinberg
Tagcloud (Difference) ?			1n9 angus asb3 backfat corticotropin crossbreeding dermatan desaturase dsel efemp1 epimerase fibulin hardy healthful heterosis linolenic marbling oleic overdominant palmitic parentage pltp sires slc27a1 slc27a2 solute wagyu wagyuxangus weinberg
Tagcloud (Intersection) ?