GNB4 and GNG5

Number of citations of the paper that reports this interaction (PMID 8636150)
15

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		GNB4	GNG5
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 4	guanine nucleotide binding protein (G protein), gamma 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Extracellular Vesicular Exosome	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Complex Binding	GTPase Activity Signal Transducer Activity PDZ Domain Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Substantia Nigra Development Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport GPCR ligand binding beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		17 interactors: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MTNR1A MTNR1B	12 interactors: AMOTL2 EPS15L1 GNB1 GNB2 GNB3 GNB4 GNB5 GOLGA2 KRT31 KRT40 MDFI TRAF1
Entrez ID		59345	2787
HPRD ID		09973	11865
Ensembl ID			ENSG00000174021
Uniprot IDs		Q9HAV0	P63218
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Response To Peptide Hormone Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Response To Hormone Signal Transduction Signaling Cell Communication Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Oxidation-reduction Process Response To Stimulus Cellular Response To Organic Substance Response To Organic Substance Small Molecule Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Platelet Activation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Phototransduction Regulation Of CAMP Metabolic Process Detection Of Light Stimulus Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Body Fluid Levels Vesicle Fusion Wound Healing Cell Activation	Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Signal Transduction Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Rhodopsin Mediated Signaling Pathway Signaling Rhodopsin Mediated Signaling Pathway Cell Communication Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Organonitrogen Compound Phototransduction, Visible Light Response To Hormone Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Binding Detection Of Light Stimulus Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Response To Stimulus Cellular Response To Radiation Synaptic Transmission Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Oxidation-reduction Process Regulation Of Signal Transduction Regulation Of Binding Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Organic Substance Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Trophoblast Giant Cell Differentiation Regulation Of Signaling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity
Tagcloud ?			adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng12 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Difference) ?			adcy8 adcy9 br1 br2 consisted disturbance endometrial endometrium eventually fos g2 g3 gnb1 gng11 gng12 kinin kinins kras map2k2 mapk1 microarrays mitogenic oligonucleotide plcb4 prkacb prkar1a prkca reaching u133a
Tagcloud (Intersection) ?