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GNB4 and GNAI1
Number of citations of the paper that reports this interaction (PMID
16371464
)
32
Data Source:
BioGRID
(fluorescent resonance energy transfer)
GNB4
GNAI1
Gene Name
guanine nucleotide binding protein (G protein), beta polypeptide 4
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Lysosomal Membrane
Plasma Membrane
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Lysosomal Membrane
Centrosome
Heterotrimeric G-protein Complex
Plasma Membrane
Midbody
Extracellular Vesicular Exosome
Molecular Function
Signal Transducer Activity
Protein Complex Binding
GTPase Activity
Signal Transducer Activity
Protein Binding
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
G-protein Coupled Serotonin Receptor Binding
Metal Ion Binding
Biological Process
Energy Reserve Metabolic Process
Signal Transduction
Substantia Nigra Development
Small Molecule Metabolic Process
Cellular Response To Glucagon Stimulus
Cell Cycle
G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Synaptic Transmission
Blood Coagulation
Platelet Activation
Response To Peptide Hormone
Cell Division
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
G alpha (q) signalling events
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Glucagon-type ligand receptors
Signal amplification
Signaling by Wnt
G beta:gamma signalling through PLC beta
Metabolic disorders of biological oxidation enzymes
G beta:gamma signalling through PI3Kgamma
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (12/13) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Class B/2 (Secretin family receptors)
ADP signalling through P2Y purinoceptor 12
Glucagon signaling in metabolic regulation
Prostacyclin signalling through prostacyclin receptor
G-protein beta:gamma signalling
Vasopressin regulates renal water homeostasis via Aquaporins
Opioid Signalling
Regulation of insulin secretion
Activation of Kainate Receptors upon glutamate binding
Aquaporin-mediated transport
GPCR ligand binding
beta-catenin independent WNT signaling
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
GPCR downstream signaling
Platelet homeostasis
Ca2+ pathway
G-protein activation
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
Signaling by GPCR
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Signal amplification
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
GABA B receptor activation
Adenylate cyclase inhibitory pathway
GABA receptor activation
PLC beta mediated events
Opioid Signalling
Regulation of insulin secretion
G-protein mediated events
Adrenaline,noradrenaline inhibits insulin secretion
Inhibition of adenylate cyclase pathway
Adenylate cyclase inhibitory pathway
GPCR downstream signaling
G-protein activation
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Heart rate (
23583979
)
Protein-Protein Interactions
17 interactors:
GNAI1
GNAI2
GNAI3
GNG10
GNG11
GNG12
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GNGT1
GNGT2
MTNR1A
MTNR1B
57 interactors:
ADCY5
ADRA2A
CCR5
CD47
CNR1
CRHR1
CXCR4
DRD3
EPOR
ESR1
FFAR1
GNAO1
GNB2
GNB4
GPR1
GPR143
GPSM1
GPSM2
GPSM3
HRH4
HTR2A
IGF1R
KLHL3
MTNR1A
MTNR1B
NGB
NUCB1
NUMA1
OPRD1
OPRM1
PDE6D
PTPRU
RANGAP1
RASD1
RGS10
RGS12
RGS14
RGS16
RGS17
RGS18
RGS19
RGS20
RGS4
RGS7
RIC8A
S1PR1
S1PR2
S1PR3
S1PR4
S1PR5
SSTR2
SSTR3
STRN
THAP7
TSHR
VIPR1
WASF1
Entrez ID
59345
2770
HPRD ID
09973
00756
Ensembl ID
ENSG00000127955
Uniprot IDs
Q9HAV0
P63096
PDB IDs
1KJY
1Y3A
2G83
2GTP
2IK8
2OM2
2PZ3
2XNS
3ONW
3QE0
3QI2
3UMR
3UMS
4G5Q
Enriched GO Terms of Interacting Partners
?
Cellular Response To Glucagon Stimulus
Response To Glucagon
G-protein Coupled Receptor Signaling Pathway
Synaptic Transmission
Energy Reserve Metabolic Process
Cell-cell Signaling
Response To Peptide Hormone
Cell Surface Receptor Signaling Pathway
Energy Derivation By Oxidation Of Organic Compounds
Cellular Response To Peptide Hormone Stimulus
Response To Peptide
Cellular Response To Peptide
Generation Of Precursor Metabolites And Energy
Cellular Response To Organonitrogen Compound
Response To Organonitrogen Compound
Cellular Response To Hormone Stimulus
Response To Hormone
Signal Transduction
Signaling
Cell Communication
Cellular Response To Stimulus
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Oxidation-reduction Process
Response To Stimulus
Cellular Response To Organic Substance
Response To Organic Substance
Small Molecule Metabolic Process
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Cellular Process
Regulation Of Adenylate Cyclase Activity
Platelet Activation
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Regulation Of Cyclase Activity
Regulation Of CAMP Biosynthetic Process
Phototransduction
Regulation Of CAMP Metabolic Process
Detection Of Light Stimulus
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Negative Regulation Of CAMP Biosynthetic Process
Blood Coagulation
Hemostasis
Negative Regulation Of CAMP Metabolic Process
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Detection Of Abiotic Stimulus
Negative Regulation Of Nucleotide Metabolic Process
Regulation Of Body Fluid Levels
Vesicle Fusion
Wound Healing
Cell Activation
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Cell Surface Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Signal Transduction
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Signaling
Cell Communication
Regulation Of Catalytic Activity
Termination Of G-protein Coupled Receptor Signaling Pathway
Termination Of Signal Transduction
Cellular Response To Stimulus
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Response To Stimulus
Regulation Of Signaling
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Sphingosine-1-phosphate Signaling Pathway
Regulation Of Cellular Process
Chemical Homeostasis
Cell-cell Signaling
Cytosolic Calcium Ion Homeostasis
Positive Regulation Of GTPase Activity
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Synaptic Transmission
Negative Regulation Of Signaling
Behavior
Cellular Metal Ion Homeostasis
Neuropeptide Signaling Pathway
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Cellular Cation Homeostasis
Ion Homeostasis
Cellular Ion Homeostasis
Homeostatic Process
Metal Ion Homeostasis
Negative Regulation Of Signal Transduction
Cellular Chemical Homeostasis
Locomotory Behavior
Response To Ammonium Ion
Negative Regulation Of Ion Transport
Response To Cocaine
Regulation Of Cell Proliferation
Neurological System Process
Tagcloud
?
alkenes
azotic
constructions
gnao1
heterocycle
hm
hms
htr1b
htr2a
htr2b
htr4
htr6
htr7
kpnb1
pharmacopeia
prkaca
prkca
prkcb
prkcd
prkce
prkcg
prkd1
propertied
pubchem
rock2
rps6ka1
rps6ka3
tlr8
tradition
Tagcloud (Difference)
?
alkenes
azotic
constructions
gnao1
heterocycle
hm
hms
htr1b
htr2a
htr2b
htr4
htr6
htr7
kpnb1
pharmacopeia
prkaca
prkca
prkcb
prkcd
prkce
prkcg
prkd1
propertied
pubchem
rock2
rps6ka1
rps6ka3
tlr8
tradition
Tagcloud (Intersection)
?