GNAI1 and PTEN

Number of citations of the paper that reports this interaction (PubMedID 26561776)
0

Data Source:
BioGRID (pull down)

		GNAI1	PTEN
Description		G protein subunit alpha i1	phosphatase and tensin homolog
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Cell Cortex Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Apical Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase Inhibitor Activity Hydrolase Activity Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding D2 Dopamine Receptor Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity Enzyme Binding PDZ Domain Binding Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Identical Protein Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity Molecular Function Inhibitor Activity Ubiquitin-specific Protease Binding Ubiquitin Ligase Activator Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Neuropeptide Signaling Pathway Response To Prostaglandin E Response To Peptide Hormone Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Insulin Secretion Cell Division Regulation Of Mitotic Spindle Organization Chemokine-mediated Signaling Pathway T Cell Migration Positive Regulation Of Relaxation Of Smooth Muscle Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex	Osteoblast Differentiation Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Spindle Assembly Involved In Female Meiosis Neuron-neuron Synaptic Transmission Nervous System Development Synapse Assembly Central Nervous System Development Heart Development Learning Or Memory Locomotory Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Migration Adult Behavior Regulation Of Protein Stability Central Nervous System Myelin Maintenance Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Social Behavior Maternal Behavior Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Locomotor Rhythm Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Organ Growth Phosphatidylinositol Dephosphorylation Forebrain Morphogenesis Cell Motility Negative Regulation Of Axonogenesis Protein Stabilization Negative Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Keratinocyte Migration Regulation Of Cell Cycle Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhythmic Synaptic Transmission Synapse Maturation Prepulse Inhibition Dendritic Spine Morphogenesis Regulation Of Biological Quality Cellular Response To Electrical Stimulus Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2
Drugs		Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion	Phosphatidylethanolamine
Diseases			Vulvar cancer Breast cancer Malignant melanoma Prostate cancer Hepatocellular carcinoma Small cell lung cancer Endometrial Cancer Glioma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Nicotine dependence ( 33144568) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)	Alanine aminotransferase levels ( 33547301) Ambidextrousness ( 32989287) Birth weight ( 31043758) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fasting insulin ( 34059833) Height ( 31562340) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mercury levels ( 26025379) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 32888494) Plateletcrit ( 32888494) Psoriasis ( 28537254) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Thyroid stimulating hormone levels ( 32769997 30367059) Type 2 diabetes ( 32499647 24509480) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		63 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CMKLR2 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB1 GNB2 GNB4 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SNCA SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	376 interacting genes: AATK ABCF2 ACTL6A ADAR AFP AKAP12 AKT1 ALYREF AMOT ANAPC10 ANAPC7 ANG ANP32B ANP32E ANXA2 AR ARF4 ARMCX3 ASCC3 ATM ATP5F1A ATP5F1C BCAR1 BEX1 BGLT3 BUB3 CACTIN-AS1 CAD CALM1 CAMK2G CAV1 CBL CCDC180 CCDC47 CCND2 CCT2 CCT3 CCT4 CCT6A CCT8 CDC27 CEP170 CEP97 CFL1 CHD4 CHGB CMAS COPA COPB1 COPS6 CREB1 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 CXXC1 DAP3 DAXX DBN1 DCAF11 DCAF13 DDB1 DDOST DDX1 DDX21 DDX24 DDX47 DDX50 DHX15 DHX9 DLC1 DLG1 DNAJA1 DNAJA2 DNAJA3 DNAJB6 DNAJC10 DPM1 DRG1 DSP EEF2 EIF4E EIF6 EML1 EPHA2 EPRS1 ERBB3 ESR1 EXOSC1 EXOSC2 EXOSC4 EXOSC5 EXOSC7 FARSA FARSB FASN FBL FBXW11 FLNA FOXK1 FUBP3 GEMIN4 GNAI1 GNAI2 GNB4 GNL3 GPC4 GSTM2 GTF3C2 GTF3C3 GTF3C5 H2AC4 H2AX HADHA HBA1 HNRNPA1 HNRNPA3 HNRNPAB HNRNPUL1 HSD17B1 HSD17B10 HSP90B1 HSPA4 HSPA4L HSPA8 HSPBP1 HSPD1 HSPH1 IL24 ILF2 ILF3 INS IPO5 IPO7 IRS4 ITPRID2 JUP KBTBD4 KDM1A KPNB1 LATS1 LGALS1 LIMA1 LINC00839 LINC01198 LINC02023 LMNB1 LRPPRC LTV1 MAGED2 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MATR3 MCM2 MCM3 MCM5 MCRS1 MDC1 MDN1 METTL26 MEX3C MKI67 MME MPRIP MRPS22 MRPS23 MRPS27 MRPS28 MRPS7 MRPS9 MSH6 MTHFD2 MVP MYBBP1A MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NACA NCBP1 NCF1 NDFIP1 NEDD4 NGB NHERF1 NHERF2 NOP56 NOP58 NPM3 NUMB OSGIN1 PBK PBRM1 PCNA PDGFRB PELO PELP1 PHB1 PHB2 PICK1 PIK3R1 PKM PLEC PLK1 POLDIP2 POLR1A POLR2A POLR2B POLR2H POP1 PPL PPP1CA PPP2CA PRDX1 PRDX3 PRKDC PRPF19 PRPF8 PSMD3 PSMD4 PSMD7 PTDSS1 PTK7 PURA PXN QPCTL RAD21 RANBP2 RANGAP1 RBBP5 RBM4 RCC2 RCN1 RFC3 RFC4 RFC5 RING1 RNF31 RPL10 RPL10A RPL12 RPL13 RPL13A RPL14 RPL17 RPL18A RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL27 RPL27A RPL28 RPL30 RPL31 RPL32 RPL34 RPL36 RPL38 RPL7 RPLP0 RPLP2 RPN2 RPP30 RPP38 RPP40 RPS11 RPS13 RPS15 RPS15A RPS17 RPS2 RPS20 RPS23 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS5 RPS6 RPS9 RSL1D1 RYBP S100A8 S100A9 SDC1 SDC4 SDCBP SEC61A1 SET SETX SHARPIN SHROOM3 SIN3A SIRT4 SKP1 SLC25A1 SLC25A13 SLC25A3 SLC25A5 SMARCA4 SMARCA5 SMC2 SMC4 SMCHD1 SMURF1 SNAI1 SNRNP200 SNRPA1 SNRPB2 SNRPD1 SNTB2 SNX27 SPOP SPTAN1 SPTBN1 SRP14 SSB SSR4 SSRP1 STAG2 STK11 STRAP SUDS3 SUGP2 TCF25 TCP1 TECR TERF2IP THOC2 THOC3 THOC6 TMEFF1 TNKS TNKS2 TNPO3 TP53 TP53BP1 TRIM25 TRIM28 TRMO TUBA1B TUBB TUBB4B TUFM TWIST1 TXN U2AF1 UBE2I UBE2L3 UPF1 USP7 USP9X UTP14A UTRN WWP1 WWP2 XRCC5 XRCC6 YAF2 YAP1 YES1 YTHDC2 YTHDF2 ZNF326
Entrez ID		2770	5728
HPRD ID		00756	03431
Ensembl ID		ENSG00000127955	ENSG00000171862
Uniprot IDs		P63096	F6KD01 P60484
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM 7CMU 7CMV 7DB6 7DW9 7E2X 7E2Y 7E2Z 7E32 7E33 7E9G 7EB2 7EJX 7EO2 7EO4 7EUO 7EVY 7EVZ 7EW0 7EW1 7EW2 7EW3 7EW4 7EW7 7EXD 7EZH 7EZK 7EZM 7F1Q 7F1R 7F1S 7F4D 7F4F 7F4H 7F4I 7JHJ 7JVR 7L0P 7L0Q 7L0R 7L0S 7MTS 7NA7 7NA8 7O7F 7P02 7RKM 7RKN 7RKX 7RKY 7S8M 7S8O 7SBF 7SCG 7SQO 7T2G 7T2H 7T6B 7T6S 7T6T 7T6U 7T6V 7TRK 7TRP 7TRQ 7TRS 7TUZ 7U2K 7U2L 7V68 7V69 7V6A 7V9L 7VAB 7VDH 7VDL 7VDM 7VFX 7VGX 7VGY 7VGZ 7VH0 7VIE 7VIF 7VIG 7VIH 7VKT 7VL8 7VL9 7VLA 7VUG 7VUY 7VUZ 7VV3 7VV5 7W0L 7W0M 7W0N 7W0O 7W0P 7WF7 7WIC 7WIG 7WJ5 7WQ3 7WU4 7WU5 7WU9 7WUI 7WUJ 7WVU 7WYB 7WZ4 7X2V 7X5H 7X9A 7X9B 7X9C 7X9Y 7XA3 7XAT 7XAU 7XAV 7XBW 7XBX 7XK2 7XK8 7XMR 7XMS 7XMT 7XTA 7XXH 7Y12 7Y15 7Y1F 7Y64 7Y65 7Y66 7Y67 7Y89 7YAC 7YAE 7YDJ 7YDP 7YKD 7YON 7YOO 7YU3 7YU5 7YU6 7YU7 7YU8 8DZP 8EF5 8EF6 8EFB 8EFL 8EFO 8EFQ 8F7Q 8F7R 8F7S 8F7W 8F7X 8FEG 8FY8 8FYE 8FYL 8FYT 8FYX 8G05 8G59 8G94 8GAG 8GCM 8GCP 8GDC 8GHV 8GUQ 8GUR 8GUS 8GUT 8H2G 8H4I 8HBD 8HK2 8HK3 8HK5 8HN8 8HNK 8HNL 8HNM 8HOC 8HQE 8HQM 8HQN 8HS3 8HSC 8HVI 8I7V 8I7W 8IA8 8IC0 8ID3 8ID4 8ID6 8ID8 8ID9 8IHB 8IHF 8IHH 8IHI 8IHJ 8IJ3 8IJA 8IJB 8IJD 8IKG 8IKH 8INR 8IOC 8IOD 8IRS 8IRT 8IRV 8IU2 8IW4 8IW7 8IW9 8IY5 8IZ4 8J18 8J19 8J1A 8J20 8J21 8J22 8J23 8J24 8J6I 8J6J 8J6L 8J6P 8J6Q 8J6R 8JD3 8JD5 8JEF 8JEI 8JGB 8JGG 8JHY 8JII 8JIL 8JIM 8JIP 8JIR 8JIS 8JJP 8JLJ 8JLK 8JLR 8JPN 8JR9 8JSO 8JSP 8JT6 8JXT 8JXV 8JXW 8JXX 8JZ7 8K2X 8K3Z 8K4N 8K4O 8K4P 8KFX 8KFY 8KFZ 8P12 8P13 8P15 8PJK 8PKM 8SAI 8SG1 8U1U 8U4N 8U4O 8U4P 8U4Q 8UGY 8UH3 8UTD 8UUJ 8VVE 8VVF 8VVG 8VY7 8W8B 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WCA 8WG8 8WOG 8WP1 8WRB 8WSS 8WW2 8WWH 8WWI 8WWJ 8WWK 8WWL 8WWM 8WWN 8X3L 8XBE 8XBH 8XGM 8XGU 8XML 8XOR 8XOS 8XQE 8XQF 8XQN 8XQO 8XQS 8XQT 8XWP 8XWQ 8XXU 8XXV 8XYD 8XZF 8XZG 8XZH 8XZI 8XZJ 8Y01 8Y62 8Y63 8YH0 8YH2 8YIC 8YKV 8YKW 8YKX 8YN5 8YN6 8YN9 8YNA 8YUT 8YUU 8YUV 8Z7J 8ZBE 8ZCJ 8ZJD 8ZJE 8ZJG 8ZQE 9AST 9AVG 9AYF 9B54 9B65 9BQJ 9D61 9EPP 9EPQ 9EPR 9ERX 9IJ9 9IQT 9IVG 9IVM 9IYB 9IZF 9J1P 9K1C 9K1D 9K26 9L3W 9L3Y	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ 7JTX 7JUK 7JUL 7JVX 7PC7 8X3S
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Sphingosine-1-phosphate Receptor Activity Membrane GTPase Regulator Activity Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Negative Regulation Of Transport G Protein-coupled Peptide Receptor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Synapse GTPase Activator Activity Neuropeptide Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Adult Behavior Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse Regulation Of Signal Transduction Norepinephrine Binding GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Secretion Negative Regulation Of Protein Transport Behavioral Response To Cocaine Regulation Of Amine Transport Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Transport Regulation Of Metal Ion Transport Negative Regulation Of Establishment Of Protein Localization Dendrite Response To Alkaloid G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Negative Regulation Of Signal Transduction Neuropeptide Signaling Pathway Regulation Of Monoatomic Ion Transport	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Macromolecule Metabolic Process Translation Nucleolus Nucleoplasm Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cytosol Nucleus Cytosolic Large Ribosomal Subunit Cytoplasm RNA Metabolic Process Extracellular Exosome Focal Adhesion RRNA Metabolic Process Protein Metabolic Process Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of DNA Metabolic Process Protein Binding Small Ribosomal Subunit ATP Binding Chromosome, Telomeric Region ATP Hydrolysis Activity Small-subunit Processome Positive Regulation Of DNA Biosynthetic Process RRNA Processing Positive Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ribosomal Small Subunit Biogenesis MRNA Metabolic Process Nucleotide Binding DNA Metabolic Process Protein Localization To Organelle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus ATP-dependent Protein Folding Chaperone Positive Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Via Telomerase Chromosome Cadherin Binding
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