GNAI1 and IGF1R

Number of citations of the paper that reports this interaction (PubMedID 10644671)
0

Data Source:
HPRD (in vivo)

		GNAI1	IGF1R
Description		G protein subunit alpha i1	insulin like growth factor 1 receptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Cell Cortex Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Nucleolus Plasma Membrane Insulin Receptor Complex Cilium Membrane Axon Alphav-beta3 Integrin-IGF-1-IGF1R Complex Receptor Complex Protein Kinase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase Inhibitor Activity Hydrolase Activity Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding D2 Dopamine Receptor Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Activity Insulin-like Growth Factor Receptor Activity Insulin Receptor Binding Structural Molecule Activity Protein Binding Insulin-like Growth Factor Binding ATP Binding Kinase Activity Transferase Activity Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein Transporter Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Neuropeptide Signaling Pathway Response To Prostaglandin E Response To Peptide Hormone Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Insulin Secretion Cell Division Regulation Of Mitotic Spindle Organization Chemokine-mediated Signaling Pathway T Cell Migration Positive Regulation Of Relaxation Of Smooth Muscle Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex	Immune Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transcytosis Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Glucose Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxygen-containing Compound Cellular Response To Amyloid-beta
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling Respiratory syncytial virus (RSV) attachment and entry
Drugs		Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion	Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Nandrolone decanoate Somatrem Insulin beef Insulin degludec Insulin argine Insulin peglispro Insulin tregopil Dalotuzumab Cixutumumab Brigatinib Mecasermin rinfabate BMS-754807 KW-2450 free base
Diseases			Synovial sarcoma Malignant pleural mesothelioma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Nicotine dependence ( 33144568) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)	Adult body size ( 32376654) Alzheimer's disease ( 33074286) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 22354554) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29124443 29403010) Dental caries (decayed and filled deciduous teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometriosis ( 27506219) Estimated glomerular filtration rate ( 31015462 31152163 30604766 29124443) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Height ( 25429064 31562340 33713608 20881960 34270706 28552196) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hyperuricemia ( 29124443) Left ventricle wall thickness ( 33495596) Left ventricular mass ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Offspring birth weight ( 31043758) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) QRS duration ( 30012220) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 29403010 30993211 29124443) Smoking status (ever vs never smokers) ( 30643258) Thyroid volume in Hashimoto’s thyroiditis ( 32019955) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urate levels ( 31578528 31985003 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		63 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CMKLR2 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB1 GNB2 GNB4 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SNCA SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	95 interacting genes: AMY2A APP ARHGEF12 BAP1 CAV1 CBL CDK4 CDKN2B CRK CRKL CSK CYP17A1 DOK4 DOK5 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 EEA1 EHD1 ERBB2 ESR1 FFAR2 FGFR4 GIPC1 GNAI1 GNAI2 GRB10 GRB14 GRM1 HOXC6 IGF1 IGF2 IGFBP3 IL13RA2 ILKAP INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KDELR2 KL KLK5 KRT27 LYPD3 MAP3K5 MDM2 MTA3 NAT2 NEDD4 NF2 PIK3R1 PIK3R2 PIK3R3 PPM1A PRKCD PRKD1 PRNP PTPN1 PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RACK1 RASA1 RELA RPL11 SH2B1 SHC1 SIRPA SOCS1 SOCS2 SOCS3 SRC STAT3 STYX THRSP TTYH2 UBC VAV3 VPS45 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		2770	3480
HPRD ID		00756	00932
Ensembl ID		ENSG00000127955	ENSG00000140443
Uniprot IDs		P63096	C9J5X1 P08069
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM 7CMU 7CMV 7DB6 7DW9 7E2X 7E2Y 7E2Z 7E32 7E33 7E9G 7EB2 7EJX 7EO2 7EO4 7EUO 7EVY 7EVZ 7EW0 7EW1 7EW2 7EW3 7EW4 7EW7 7EXD 7EZH 7EZK 7EZM 7F1Q 7F1R 7F1S 7F4D 7F4F 7F4H 7F4I 7JHJ 7JVR 7L0P 7L0Q 7L0R 7L0S 7MTS 7NA7 7NA8 7O7F 7P02 7RKM 7RKN 7RKX 7RKY 7S8M 7S8O 7SBF 7SCG 7SQO 7T2G 7T2H 7T6B 7T6S 7T6T 7T6U 7T6V 7TRK 7TRP 7TRQ 7TRS 7TUZ 7U2K 7U2L 7V68 7V69 7V6A 7V9L 7VAB 7VDH 7VDL 7VDM 7VFX 7VGX 7VGY 7VGZ 7VH0 7VIE 7VIF 7VIG 7VIH 7VKT 7VL8 7VL9 7VLA 7VUG 7VUY 7VUZ 7VV3 7VV5 7W0L 7W0M 7W0N 7W0O 7W0P 7WF7 7WIC 7WIG 7WJ5 7WQ3 7WU4 7WU5 7WU9 7WUI 7WUJ 7WVU 7WYB 7WZ4 7X2V 7X5H 7X9A 7X9B 7X9C 7X9Y 7XA3 7XAT 7XAU 7XAV 7XBW 7XBX 7XK2 7XK8 7XMR 7XMS 7XMT 7XTA 7XXH 7Y12 7Y15 7Y1F 7Y64 7Y65 7Y66 7Y67 7Y89 7YAC 7YAE 7YDJ 7YDP 7YKD 7YON 7YOO 7YU3 7YU5 7YU6 7YU7 7YU8 8DZP 8EF5 8EF6 8EFB 8EFL 8EFO 8EFQ 8F7Q 8F7R 8F7S 8F7W 8F7X 8FEG 8FY8 8FYE 8FYL 8FYT 8FYX 8G05 8G59 8G94 8GAG 8GCM 8GCP 8GDC 8GHV 8GUQ 8GUR 8GUS 8GUT 8H2G 8H4I 8HBD 8HK2 8HK3 8HK5 8HN8 8HNK 8HNL 8HNM 8HOC 8HQE 8HQM 8HQN 8HS3 8HSC 8HVI 8I7V 8I7W 8IA8 8IC0 8ID3 8ID4 8ID6 8ID8 8ID9 8IHB 8IHF 8IHH 8IHI 8IHJ 8IJ3 8IJA 8IJB 8IJD 8IKG 8IKH 8INR 8IOC 8IOD 8IRS 8IRT 8IRV 8IU2 8IW4 8IW7 8IW9 8IY5 8IZ4 8J18 8J19 8J1A 8J20 8J21 8J22 8J23 8J24 8J6I 8J6J 8J6L 8J6P 8J6Q 8J6R 8JD3 8JD5 8JEF 8JEI 8JGB 8JGG 8JHY 8JII 8JIL 8JIM 8JIP 8JIR 8JIS 8JJP 8JLJ 8JLK 8JLR 8JPN 8JR9 8JSO 8JSP 8JT6 8JXT 8JXV 8JXW 8JXX 8JZ7 8K2X 8K3Z 8K4N 8K4O 8K4P 8KFX 8KFY 8KFZ 8P12 8P13 8P15 8PJK 8PKM 8SAI 8SG1 8U1U 8U4N 8U4O 8U4P 8U4Q 8UGY 8UH3 8UTD 8UUJ 8VVE 8VVF 8VVG 8VY7 8W8B 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WCA 8WG8 8WOG 8WP1 8WRB 8WSS 8WW2 8WWH 8WWI 8WWJ 8WWK 8WWL 8WWM 8WWN 8X3L 8XBE 8XBH 8XGM 8XGU 8XML 8XOR 8XOS 8XQE 8XQF 8XQN 8XQO 8XQS 8XQT 8XWP 8XWQ 8XXU 8XXV 8XYD 8XZF 8XZG 8XZH 8XZI 8XZJ 8Y01 8Y62 8Y63 8YH0 8YH2 8YIC 8YKV 8YKW 8YKX 8YN5 8YN6 8YN9 8YNA 8YUT 8YUU 8YUV 8Z7J 8ZBE 8ZCJ 8ZJD 8ZJE 8ZJG 8ZQE 9AST 9AVG 9AYF 9B54 9B65 9BQJ 9D61 9EPP 9EPQ 9EPR 9ERX 9IJ9 9IQT 9IVG 9IVM 9IYB 9IZF 9J1P 9K1C 9K1D 9K26 9L3W 9L3Y	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN 5U8Q 5U8R 6JK8 6VWG 6VWH 6VWI 6VWJ 7PH8 7S0Q 7S8V 7U23 7V3P 7XGD 7XLC 7YRR 8PYI 8PYJ 8PYK 8PYL 8PYM 8PYN 8TAN
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Sphingosine-1-phosphate Receptor Activity Membrane GTPase Regulator Activity Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Negative Regulation Of Transport G Protein-coupled Peptide Receptor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Synapse GTPase Activator Activity Neuropeptide Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Adult Behavior Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse Regulation Of Signal Transduction Norepinephrine Binding GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Secretion Negative Regulation Of Protein Transport Behavioral Response To Cocaine Regulation Of Amine Transport Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Locomotory Behavior Regulation Of Transport Regulation Of Metal Ion Transport Negative Regulation Of Establishment Of Protein Localization Dendrite Response To Alkaloid G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Negative Regulation Of Signal Transduction Neuropeptide Signaling Pathway Regulation Of Monoatomic Ion Transport	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Insulin-like Growth Factor Receptor Binding Insulin Receptor Binding Negative Regulation Of Signal Transduction Intracellular Signal Transduction Insulin Receptor Signaling Pathway Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Localization Protein Tyrosine Phosphatase Activity Response To Peptide Hormone Positive Regulation Of MAPK Cascade Regulation Of Cellular Localization Positive Regulation Of Protein Localization Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Intracellular Signal Transduction Cytosol Response To Growth Factor Regulation Of Establishment Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Cell Population Proliferation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Transport Response To Hormone Dephosphorylation Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAPK Cascade Intracellular Signaling Cassette
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