UBR4 and PRPF40A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR4	PRPF40A
Gene Name		ubiquitin protein ligase E3 component n-recognin 4	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Membrane Nuclear Matrix Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Ligase Activity	Protein Binding Poly(A) RNA Binding Proline-rich Region Binding
	Biological Process	Viral Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	MRNA Processing Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis Cell Division
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PRPF40A SRGN UBC	120 interactors: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BRD4 CAP2 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CSNK2A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDX46 DHX15 DHX8 DHX9 DIAPH1 ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SRPK2 STIM2 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WBP5 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		23352	55660
HPRD ID		10184	10995
Ensembl ID		ENSG00000127481	ENSG00000196504
Uniprot IDs		Q5T4S7	O75400 Q05C41
PDB IDs			1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS
Enriched GO Terms of Interacting Partners?		Maintenance Of Granzyme B Location In T Cell Secretory Granule T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Negative Regulation Of Cytokine Production Mast Cell Secretory Granule Organization Protein Processing Granzyme-mediated Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Viral Protein Processing Regulation Of Cytokine Production Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Cell Cycle Negative Regulation Of Cytokine Secretion Apoptotic Process Cellular Polysaccharide Biosynthetic Process Secretory Granule Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Death Death Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway	RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Process Cellular Metabolic Process Cellular Component Assembly Actin Cytoskeleton Organization MRNA 3'-splice Site Recognition Actin Polymerization Or Depolymerization Actin Filament-based Process Cytoskeleton Organization RNA Biosynthetic Process Regulation Of Organelle Organization Transcription, DNA-templated Organelle Organization Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Component Organization CRD-mediated MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Protein Sumoylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of RNA Splicing Cell Differentiation Negative Regulation Of Cellular Metabolic Process Actin Filament Organization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Multicellular Organismal Development Spliceosomal Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of RNA Metabolic Process Developmental Process
Tagcloud ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity ptpn21 q22 sawtooth sec63 sptlc3 unsupervised	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic
Tagcloud (Difference) ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity ptpn21 q22 sawtooth sec63 sptlc3 unsupervised	arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic
Tagcloud (Intersection) ?