UBR4

Description		ubiquitin protein ligase E3 component n-recognin 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Fatty Acid Biosynthetic Process Response To Oxidative Stress Endosome Organization Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process Protein Stabilization Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling Protein Branched Polyubiquitination
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Verpasep caltespen Picolinic acid
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)
Interacting Genes		18 interacting genes: ACE2 ADRA1A AGTR1 CALM1 ERG HSPA13 MTNR1A MTNR1B MYCN PRPF40A SRGN SRPK2 SUMO2 TTC3 UBC UBE2B UBE2D2 UBE2L3
Entrez ID		23352
HPRD ID		10184
Ensembl ID		ENSG00000127481
Uniprot IDs		Q5T4S7
PDB IDs		8B5W 8BTL 8J9Q 8J9R
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Regulation Of Blood Circulation Melatonin Receptor Activity Ubiquitin Conjugating Enzyme Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Action Potential Positive Regulation Of Cardiac Muscle Contraction Protein Modification By Small Protein Conjugation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Nucleoplasm Positive Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction Protein Modification Process Proteolysis Protein Tag Activity Ubiquitin-protein Transferase Activity Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of System Process Protein Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Circulatory System Process Protein Ubiquitination Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Reactive Oxygen Species Metabolic Process Presynaptic Cytosol G Protein-coupled Receptor Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Muscle Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Protein K11-linked Ubiquitination G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Angiotensin Type I Receptor Activity Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Regulation Of Heart Contraction Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
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