UBR4 and SRGN

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UBR4	SRGN
Gene Name		ubiquitin protein ligase E3 component n-recognin 4	serglycin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Membrane Integral Component Of Membrane	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Platelet Alpha Granule Lumen Zymogen Granule Mast Cell Granule
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Ligase Activity	Protein Binding Collagen Binding
	Biological Process	Viral Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Platelet Degranulation Blood Coagulation Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Platelet Activation Negative Regulation Of Bone Mineralization Biomineral Tissue Development Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Negative Regulation Of Cytokine Secretion
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PRPF40A SRGN UBC	12 interactors: ALB BAG6 CCL3 CD44 CEP70 GZMB PF4 PSRC1 SGTA UBQLN1 UBQLN4 UBR4
Entrez ID		23352	5552
HPRD ID		10184	01513
Ensembl ID		ENSG00000127481	ENSG00000122862
Uniprot IDs		Q5T4S7	P10124
PDB IDs
Enriched GO Terms of Interacting Partners?		Maintenance Of Granzyme B Location In T Cell Secretory Granule T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Negative Regulation Of Cytokine Production Mast Cell Secretory Granule Organization Protein Processing Granzyme-mediated Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Cycle Process Viral Protein Processing Regulation Of Cytokine Production Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Cell Cycle Negative Regulation Of Cytokine Secretion Apoptotic Process Cellular Polysaccharide Biosynthetic Process Secretory Granule Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Death Death Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway	Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Behavior Cytolysis Regulation Of Behavior Leukocyte Migration Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Leukocyte Chemotaxis Exocytosis Platelet Degranulation Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Leukocyte Migration Positive Regulation Of Monocyte Aggregation Maintenance Of Mitochondrion Location Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Cell Death Blood Coagulation Inflammatory Response Hemostasis Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Leukocyte Migration Monocyte Aggregation Response To Platinum Ion Negative Regulation Of Cytolysis Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Eosinophil Degranulation Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Natural Killer Cell Chemotaxis Granzyme-mediated Apoptotic Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Immune System Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Negative Regulation Of MHC Class II Biosynthetic Process Wound Healing Immune Response
Tagcloud ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity ptpn21 q22 sawtooth sec63 sptlc3 unsupervised	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a trem2 tubal3 txnrd1
Tagcloud (Difference) ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 impc impcs micropapillary pangenomic polarity ptpn21 q22 sawtooth sec63 sptlc3 unsupervised	bring btg1 cyr61 dcs e7 epha1 hla idc igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a trem2 tubal3 txnrd1
Tagcloud (Intersection) ?		idcs