PPARD and OTUD3

Number of citations of the paper that reports this interaction (PubMedID 35675826)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PPARD	OTUD3
Description		peroxisome proliferator activated receptor delta	OTU deubiquitinase 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding Linoleic Acid Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Placenta Development Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Apoptotic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Population Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process Response To Glucose Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cholesterol Storage Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Fatty Acid Oxidation Cell Differentiation Negative Regulation Of Cell Growth Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Nutrient Levels Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Wound Healing Regulation Of Cell Population Proliferation Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adipose Tissue Development Fat Cell Proliferation Positive Regulation Of Fat Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Energy Homeostasis Apoptotic Signaling Pathway Negative Regulation Of MiRNA Transcription D-glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination
Pathways		Carnitine shuttle Nuclear Receptor transcription pathway Signaling by Retinoic Acid	Ovarian tumor domain proteases Regulation of PTEN stability and activity
Drugs		alpha-Linolenic acid Icosapent Troglitazone Valproic acid Treprostinil Rosiglitazone Sulindac Bezafibrate Phthalic Acid Heptyl glucoside Oleic Acid cis-Vaccenic acid Elafibranor KD3010 Cardarine (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin Fenofibric acid Fish oil
Diseases
GWAS		Appendicular lean mass ( 33097823) Cataracts in type 2 diabetes ( 23137000) Childhood body mass index ( 33045005) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)	Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)
Interacting Genes		44 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NR1H2 NR1H3 NRIP1 OTUD3 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1 ZNF837	17 interacting genes: ATG14 BGLT3 BHLHE22 CGAS FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PPARD SIX3 STUB1 TP53 UBC UBE2L3
Entrez ID		5467	23252
HPRD ID		02679	19417
Ensembl ID		ENSG00000112033	ENSG00000169914
Uniprot IDs		F1D8S7 Q03181	Q5T2D3
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P 7F80 7VWE 7VWF 7VWG 7VWH 7W0G 7WGL 7WGN 8HF8 8HUL 8HUO	4BOU
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Chromatin Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Circadian Rhythm Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism MRNA Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Lysine Deacetylase Activity Transcription By RNA Polymerase II MRNA Transcription Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of Biosynthetic Process Histone Deacetylase Activity Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan
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