PPARD and HDAC3

Number of citations of the paper that reports this interaction (PubMedID 11867749)
37

Data Source:
HPRD (in vivo)

		PPARD	HDAC3
Description		peroxisome proliferator activated receptor delta	histone deacetylase 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding Linoleic Acid Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Cyclin Binding Chromatin DNA Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding GTPase Binding NF-kappaB Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Placenta Development Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Apoptotic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Population Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process Response To Glucose Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cholesterol Storage Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Fatty Acid Oxidation Cell Differentiation Negative Regulation Of Cell Growth Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Nutrient Levels Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Wound Healing Regulation Of Cell Population Proliferation Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adipose Tissue Development Fat Cell Proliferation Positive Regulation Of Fat Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Energy Homeostasis Apoptotic Signaling Pathway Negative Regulation Of MiRNA Transcription D-glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription By RNA Polymerase II Protein Deacetylation Regulation Of Mitotic Cell Cycle Epidermis Development Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of TOR Signaling Negative Regulation Of Interleukin-1 Production Negative Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Protein Modification Process Regulation Of Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Protein Export From Nucleus Rhythmic Process Spindle Assembly Random Inactivation Of X Chromosome Neural Precursor Cell Proliferation Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Response To Dexamethasone Negative Regulation Of Ferroptosis Positive Regulation Of Cold-induced Thermogenesis DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Ferroptosis Cornified Envelope Assembly Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Carnitine shuttle Nuclear Receptor transcription pathway Signaling by Retinoic Acid	p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		alpha-Linolenic acid Icosapent Troglitazone Valproic acid Treprostinil Rosiglitazone Sulindac Bezafibrate Phthalic Acid Heptyl glucoside Oleic Acid cis-Vaccenic acid Elafibranor KD3010 Cardarine (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin Fenofibric acid Fish oil	Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Phenylbutyric acid Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Appendicular lean mass ( 33097823) Cataracts in type 2 diabetes ( 23137000) Childhood body mass index ( 33045005) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)	Refractive error ( 32231278)
Interacting Genes		44 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NR1H2 NR1H3 NRIP1 OTUD3 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1 ZNF837	103 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 CUL4B DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16
Entrez ID		5467	8841
HPRD ID		02679	08950
Ensembl ID		ENSG00000112033	ENSG00000171720
Uniprot IDs		F1D8S7 Q03181	O15379
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P 7F80 7VWE 7VWF 7VWG 7VWH 7W0G 7WGL 7WGN 8HF8 8HUL 8HUO	4A69
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Chromatin Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Circadian Rhythm Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism MRNA Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Lysine Deacetylase Activity Transcription By RNA Polymerase II MRNA Transcription Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of Biosynthetic Process Histone Deacetylase Activity Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Histone Deacetylase Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Transcription Repressor Complex Transcription Regulator Complex DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription Chromatin Organization Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Regulation Of Developmental Process Histone Deacetylase Complex DNA-binding Transcription Factor Activity
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