HEYL and SP8

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		HEYL	SP8
Gene Name		hes-related family bHLH transcription factor with YRPW motif-like	Sp8 transcription factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Protein Homodimerization Activity Protein Heterodimerization Activity AF-1 Domain Binding	DNA Binding Metal Ion Binding
	Biological Process	Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Mesenchymal Cell Development Glomerulus Development Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To BMP Stimulus Proximal Tubule Development Negative Regulation Of Androgen Receptor Activity	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Embryonic Limb Morphogenesis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)	Bipolar disorder ( 20386566) Prostate cancer ( 23535732) Response to statin therapy ( 20339536)
Protein-Protein Interactions		18 interactors: APP ATF7IP ATXN1 HAND1 HAND2 HIPK3 HTT LAPTM5 MDFI PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B	3 interactors: HEYL ZNF273 ZNF519
Entrez ID		26508	221833
HPRD ID		16419	12208
Ensembl ID		ENSG00000163909
Uniprot IDs		F5H3V9 Q9NQ87	Q8IXZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Tube Development Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Negative Regulation Of Signaling Regulation Of Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Macromolecule Biosynthetic Process Tissue Development Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cardiac Right Ventricle Formation Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Morphogenesis Negative Regulation Of DNA Binding Embryonic Morphogenesis System Development	Negative Regulation Of Androgen Receptor Activity Proximal Tubule Development Transcription, DNA-templated RNA Biosynthetic Process Pulmonary Valve Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Formation RNA Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Atrioventricular Valve Development Gene Expression Negative Regulation Of Receptor Activity Cellular Response To BMP Stimulus Cardiac Epithelial To Mesenchymal Transition Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Ventricular Septum Morphogenesis Heart Valve Morphogenesis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Heart Valve Development Endocardial Cushion Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Ventricular Septum Development Epithelial To Mesenchymal Transition Cardiac Septum Morphogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Skeletal Muscle Cell Differentiation Outflow Tract Morphogenesis Glomerulus Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cardiac Ventricle Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cardiac Septum Development Renal Tubule Development Nitrogen Compound Metabolic Process Cardiac Ventricle Development Mesenchymal Cell Development Regulation Of Receptor Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw	1st 3rd acupuncture bilaterally detector device diji dysmenorrhea electrical electrode esr gb39 imbalance impedance menstrual menstruation pd points property reductions reflect sanyinjiao sizes sp6 statistical third uterine volunteers xuanzhong
Tagcloud (Difference) ?		bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw	1st 3rd acupuncture bilaterally detector device diji dysmenorrhea electrical electrode esr gb39 imbalance impedance menstrual menstruation pd points property reductions reflect sanyinjiao sizes sp6 statistical third uterine volunteers xuanzhong
Tagcloud (Intersection) ?