LEMD3 and SMAD9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		LEMD3	SMAD9
Gene Name		LEM domain containing 3	SMAD family member 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding
	Biological Process	Blood Vessel Endothelial Cell Migration Involved In Intussusceptive Angiogenesis Nucleus Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Skeletal Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Extracellular Matrix Organization	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound
Pathways		Mitotic Prophase Nuclear Envelope Breakdown Depolymerisation of the Nuclear Lamina Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BCLAF1 SMAD1 SMAD2 SMAD9	117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		23592	4093
HPRD ID		09704	04484
Ensembl ID		ENSG00000174106	ENSG00000120693
Uniprot IDs		Q9Y2U8	O15198
PDB IDs		2CH0
Enriched GO Terms of Interacting Partners?		Primary MiRNA Processing Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development SMAD Protein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Positive Regulation Of Transcription, DNA-templated Gene Silencing By MiRNA Cellular Response To DsRNA Urogenital System Development Posttranscriptional Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Silencing By RNA Skeletal System Development Cellular Response To Growth Factor Stimulus Response To DsRNA BMP Signaling Pathway Response To Growth Factor Mesoderm Formation Midbrain Development Embryonic Pattern Specification Mesoderm Morphogenesis Organ Growth Transcription, DNA-templated Tube Development RNA Biosynthetic Process Gene Silencing Positive Regulation Of Cellular Metabolic Process Formation Of Primary Germ Layer Positive Regulation Of Cell Differentiation Mesoderm Development Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Hindbrain Development Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry RNA Metabolic Process Gastrulation Epithelium Development	Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process
Tagcloud ?		12q13 12q14 3q14 3q15 atrial autism bands centres comprising delay deleted deletions ductus dysmorphism encompassing ended extends facial hmga2 microdeletions osteopoikilosis overlapping overlaps patent septal speech stature stenosis subtle
Tagcloud (Difference) ?		12q13 12q14 3q14 3q15 atrial autism bands centres comprising delay deleted deletions ductus dysmorphism encompassing ended extends facial hmga2 microdeletions osteopoikilosis overlapping overlaps patent septal speech stature stenosis subtle
Tagcloud (Intersection) ?