LEMD3 and BCLAF1

Number of citations of the paper that reports this interaction (PMID 15681850)
33

Data Source:
HPRD (in vitro, in vivo)

		LEMD3	BCLAF1
Gene Name		LEM domain containing 3	BCL2-associated transcription factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding	DNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Blood Vessel Endothelial Cell Migration Involved In Intussusceptive Angiogenesis Nucleus Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Skeletal Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Extracellular Matrix Organization	Transcription, DNA-templated Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Mitotic Prophase Nuclear Envelope Breakdown Depolymerisation of the Nuclear Lamina Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BCLAF1 SMAD1 SMAD2 SMAD9	9 interactors: BCL2 BCL2L1 CHD1 CLK1 CSNK2A1 EMD LEMD3 PIN1 YWHAG
Entrez ID		23592	9774
HPRD ID		09704	16544
Ensembl ID		ENSG00000174106	ENSG00000029363
Uniprot IDs		Q9Y2U8	E9PK91 Q9NYF8
PDB IDs		2CH0
Enriched GO Terms of Interacting Partners?		Primary MiRNA Processing Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development SMAD Protein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Positive Regulation Of Transcription, DNA-templated Gene Silencing By MiRNA Cellular Response To DsRNA Urogenital System Development Posttranscriptional Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Silencing By RNA Skeletal System Development Cellular Response To Growth Factor Stimulus Response To DsRNA BMP Signaling Pathway Response To Growth Factor Mesoderm Formation Midbrain Development Embryonic Pattern Specification Mesoderm Morphogenesis Organ Growth Transcription, DNA-templated Tube Development RNA Biosynthetic Process Gene Silencing Positive Regulation Of Cellular Metabolic Process Formation Of Primary Germ Layer Positive Regulation Of Cell Differentiation Mesoderm Development Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Hindbrain Development Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry RNA Metabolic Process Gastrulation Epithelium Development	Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Anoikis Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of Anoikis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Cell Cycle Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Mitochondrial Membrane Permeability Mitotic Cell Cycle Process Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Mitotic Cell Cycle Regulation Of Protein Localization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peptidyl-threonine Phosphorylation Response To Gamma Radiation Rhythmic Process Membrane Organization Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Skeletal Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Mitochondrial Membrane Organization Neuron Death Ovarian Follicle Development Cellular Response To Organic Substance Apoptotic Process Apoptotic Mitochondrial Changes Organelle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Programmed Cell Death Regulation Of Cellular Localization Cell Cycle Process Negative Regulation Of Cellular PH Reduction
Tagcloud ?		12q13 12q14 3q14 3q15 atrial autism bands centres comprising delay deleted deletions ductus dysmorphism encompassing ended extends facial hmga2 microdeletions osteopoikilosis overlapping overlaps patent septal speech stature stenosis subtle	abcb7 advance alas2 asxl1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		12q13 12q14 3q14 3q15 atrial autism bands centres comprising delay deleted deletions ductus dysmorphism encompassing ended extends facial hmga2 microdeletions osteopoikilosis overlapping overlaps patent septal speech stature stenosis subtle	abcb7 advance alas2 asxl1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?