LEMD3 and BCLAF1

Number of citations of the paper that reports this interaction (PubMedID 15681850)
0

Data Source:
HPRD (in vivo, in vitro)

		LEMD3	BCLAF1
Description		LEM domain containing 3	BCL2 associated transcription factor 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Membrane Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Mediator Complex Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding U1 SnRNP Binding	DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway	Apoptotic Process DNA Damage Response Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases		Disorders caused by loss-of-function of LEMD3, including: Osteopoikilosis; Buschke-Ollendorff syndrome (BOS); Melorheostosis
GWAS		Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		7 interacting genes: BCLAF1 RABAC1 REEP4 SMAD1 SMAD2 SMAD3 SMAD9	16 interacting genes: BCL2 BCL2L1 CEBPA CHD1 CLK1 CSNK2A1 EMD H19 LEMD3 OGT PIN1 RNF10 SRPK2 USP7 WEE2-AS1 YWHAG
Entrez ID		23592	9774
HPRD ID		09704	16544
Ensembl ID		ENSG00000174106	ENSG00000029363
Uniprot IDs		Q9Y2U8	E9PK91 Q9NYF8
PDB IDs		2CH0 5ZOJ 5ZOK	7RJN 7RJR
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Co-SMAD Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway Homomeric SMAD Protein Complex MiRNA Processing Ureteric Bud Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Paraxial Mesoderm Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Transcription Regulator Complex Embryonic Pattern Specification Mesoderm Morphogenesis Pericardium Development Kidney Epithelium Development Trophoblast Cell Migration Response To Growth Factor DEAD/H-box RNA Helicase Binding Embryonic Foregut Morphogenesis Nodal Signaling Pathway Osteoblast Differentiation Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Tube Development DNA-binding Transcription Factor Activity Positive Regulation Of Cartilage Development Endoderm Development Epithelium Development Negative Regulation Of Ossification Cellular Response To Growth Factor Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Mesoderm Formation Gastrulation Nuclear Inner Membrane Ubiquitin Protein Ligase Binding Intracellular Signaling Cassette Phosphatase Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Formation Of Primary Germ Layer	Dendritic Cell Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Catabolic Process Negative Regulation Of Cell Communication Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Protein Localization Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process BH3 Domain Binding Regulation Of Protein Stability Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process TORC1 Signaling Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Nutrient Levels Protein Stabilization TOR Signaling Cellular Response To Nutrient Levels Protein Localization To Vacuole Nuclear Membrane Regulation Of Cellular Localization Regulation Of TORC1 Signaling Negative Regulation Of Autophagy Regulation Of Translational Initiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Anoikis Negative Regulation Of Protein Metabolic Process Programmed Cell Death Involved In Cell Development Regulation Of Signal Transduction By P53 Class Mediator Sin3-type Complex Release Of Cytochrome C From Mitochondria Regulation Of Protein Metabolic Process Regulation Of Anoikis Regulation Of Cell Cycle Cellular Response To Stress Negative Regulation Of Proteolysis Regulation Of Autophagy Protein Modification Process Regulation Of Proteolysis
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