IRAK1 and H3-4

Number of citations of the paper that reports this interaction (PubMedID 18276832)
0

Data Source:
BioGRID (enzymatic study)

		IRAK1	H3-4
Description		interleukin 1 receptor associated kinase 1	H3.4 histone, cluster member
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere
Drugs		Fostamatinib
Diseases
GWAS		Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)
Interacting Genes		52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2	195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516
Entrez ID		3654	8290
HPRD ID		02235	04156
Ensembl ID		ENSG00000184216	ENSG00000168148
Uniprot IDs		D3YTB5 P51617	Q16695
PDB IDs		6BFN	2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication	Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region
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