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IRAK1 and PRKCI
Number of citations of the paper that reports this interaction (PubMedID
14684752
)
0
Data Source:
HPRD
(in vitro, in vivo)
IRAK1
PRKCI
Description
interleukin 1 receptor associated kinase 1
protein kinase C iota
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Protein-containing Complex
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Brush Border
Bicellular Tight Junction
Cilium
Microtubule Cytoskeleton
Membrane
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Apical Part Of Cell
Extracellular Exosome
Tight Junction
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
PAR Polarity Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Toll Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon-mediated Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Establishment Of Cell Polarity
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of D-glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Cellular Response To Chemical Stress
Response To Interleukin-1
Protein Localization To Plasma Membrane
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
KEAP1-NFE2L2 pathway
Drugs
Fostamatinib
Tamoxifen
Staurosporine
Bisindolylmaleimide I
Dequalinium
Benzoyl peroxide
Fostamatinib
Diseases
GWAS
Celiac disease (
22057235
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
32723749
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
19838195
26502338
26606652
26663301
33272962
)
Aspartate aminotransferase levels (
33547301
)
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31511532
31630189
)
Interacting Genes
52 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP1CC
PPP3CB
PRDX1
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TBKBP1
TICAM2
TIFA
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
USP20
YTHDC2
51 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
Entrez ID
3654
5584
HPRD ID
02235
02105
Ensembl ID
ENSG00000184216
ENSG00000163558
Uniprot IDs
D3YTB5
P51617
P41743
PDB IDs
6BFN
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
8R3X
8R3Y
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Immune System Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Innate Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Innate Immune Response
Response To External Biotic Stimulus
Cell Surface Toll-like Receptor Signaling Pathway
Response To Other Organism
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Activation Of Immune Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Lipopolysaccharide-mediated Signaling Pathway
Immune Response
Regulation Of Intracellular Signal Transduction
Defense Response To Symbiont
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of Immune System Process
Regulation Of Cytokine Production
Signal Transduction
Intracellular Signaling Cassette
Signaling Adaptor Activity
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Cytoplasm
Cytosol
Intracellular Signaling Cassette
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Localization
Intracellular Signal Transduction
Immune System Process
PAR Polarity Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Regulation Of Protein Localization
Positive Regulation Of Biosynthetic Process
Regulation Of Multicellular Organismal Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Protein Localization
Regulation Of Immune Response
Plasma Membrane
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Projection Organization
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Organelle Organization
Negative Regulation Of Programmed Cell Death
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Immune System Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Apoptotic Process
Establishment Or Maintenance Of Cell Polarity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Regulation Of Primary Metabolic Process
Regulation Of Innate Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
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