H3-4 and PIM1

Number of citations of the paper that reports this interaction (PubMedID 17643117)
0

Data Source:
HPRD (in vitro)

		H3-4	PIM1
Description		H3.4 histone, cluster member	Pim-1 proto-oncogene, serine/threonine kinase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Kinase Activity Transferase Activity Manganese Ion Binding Ribosomal Small Subunit Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation	Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Transmembrane Transporter Activity Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cytolysis In Another Organism Positive Regulation Of Cardiac Muscle Cell Proliferation Vitamin D Receptor Signaling Pathway Cellular Response To Type II Interferon Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Brown Fat Cell Differentiation Non-canonical Inflammasome Complex Assembly Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Cardioblast Proliferation Cellular Detoxification
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere	Interleukin-4 and Interleukin-13 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins
Drugs			3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine LY-294002 Imidazole (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Bisindolylmaleimide I Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Tricetin 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid Fostamatinib
Diseases
GWAS			Acne (severe) ( 24927181) Birth weight ( 31043758) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516	34 interacting genes: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A DAPK1 EGFR EPHA3 FBXO7 FH FXR2 H3-3A H3-4 H3C14 HEXIM2 HSP90AA1 NFATC1 NHLH1 NUMA1 PPP2CA PTPRO SENP1 SHMT1 SKP2 SND1 SNX6 TFPT UBE2I ZBTB1
Entrez ID		8290	5292
HPRD ID		04156	01292
Ensembl ID		ENSG00000168148	ENSG00000137193
Uniprot IDs		Q16695	P11309
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50	1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 3WE8 4A7C 4ALU 4ALV 4ALW 4AS0 4BZN 4BZO 4DTK 4ENX 4ENY 4GW8 4I41 4IAA 4JX3 4JX7 4K0Y 4K18 4K1B 4LL5 4LM5 4LMU 4MBI 4MBL 4MTA 4N6Y 4N6Z 4N70 4RBL 4RC2 4RC3 4RC4 4RPV 4TY1 4WRS 4WSY 4WT6 4XH6 4XHK 5C1Q 5DGZ 5DHJ 5DIA 5DWR 5EOL 5IIS 5IPJ 5KCX 5KGD 5KGE 5KGG 5KGI 5KGK 5KZI 5MZL 5N4N 5N4O 5N4R 5N4U 5N4V 5N4X 5N4Y 5N4Z 5N50 5N51 5N52 5N5L 5N5M 5NDT 5O11 5O12 5O13 5TEL 5TEX 5TOE 5TUR 5V80 5V82 5VUA 5VUB 5VUC 6AYD 6BSK 6KZI 6L11 6L12 6L13 6L14 6L15 6L16 6L17 6MT0 6NO8 6NO9 6PCW 6PDI 6PDN 6PDO 6PDP 6QXK 6VRU 6VRV 6YKD 7OOV 7OOW 7OOX 7QB2 7QFM 7VSY 7XSV 7Z6U 7ZUN 8AFR 8R0H 8R0Q 8R0W 8R0Y 8R10 8R18 8R1K 8R1N 8R1P 8R1T 8R1W 8R25 8R27
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region	Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Protein Heterodimerization Activity Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Nucleoplasm Positive Regulation Of DNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Mitotic Cell Cycle Phase Transition Chromosome, Centromeric Region Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cellular Response To Cell-matrix Adhesion Chromatin Organization Regulation Of Gene Expression Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of DNA Replication Nuclear Body Extracellular Exosome Regulation Of DNA Replication Protein-containing Complex Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Heterochromatin Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Protein Localization Regulation Of Protein Modification Process Cellular Response To Oxygen-containing Compound Protein Binding
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