HIST3H3 and HDAC2

Number of citations of the paper that reports this interaction (PMID 12700765)
190

Data Source:
BioGRID (enzymatic study)

		HIST3H3	HDAC2
Gene Name		histone cluster 3, H3	histone deacetylase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Transcription Factor Complex Cytoplasm Sin3 Complex NuRD Complex ESC/E(Z) Complex Protein Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Telomere Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Maintenance Of Chromatin Silencing Transcription, DNA-templated Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Gene Expression Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Hippocampus Development Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Regulation Of Gene Expression, Epigenetic Response To Cocaine Odontogenesis Of Dentin-containing Tooth Response To Drug Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Sarcomere Organization Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes	Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NoRC negatively regulates rRNA expression Signaling by NOTCH1 Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Chromatin organization HDACs deacetylate histones p75NTR negatively regulates cell cycle via SC1 RNA Polymerase I Transcription Signaling by NOTCH Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression p75 NTR receptor-mediated signalling Factors involved in megakaryocyte development and platelet production NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516	92 interactors: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LINC00152 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUV39H1 SYK TFCP2 THRA THRB TOP2A TOP2B TP53 VHL YY1 ZBTB16 ZNF461
Entrez ID		8290	3066
HPRD ID		04156	05521
Ensembl ID		ENSG00000168148	ENSG00000196591
Uniprot IDs		Q16695	Q92769
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R	3MAX 4LXZ 4LY1
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Modification Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Organelle Organization Histone Modification Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Histone Deacetylation Protein Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Cycle
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs
Tagcloud (Intersection) ?