H3-4 and FOXA1

Number of citations of the paper that reports this interaction (PubMedID 11864602)
0

Data Source:
HPRD (in vitro, in vivo)

		H3-4	FOXA1
Description		H3.4 histone, cluster member	forkhead box A1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome	Chromatin Fibrillar Center Nucleus Nucleoplasm Microvillus
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Smoothened Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Cell Differentiation Neuron Differentiation Lung Development Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Tube Morphogenesis Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Lung Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Alveolar Secondary Septum Development Connective Tissue Development Dopaminergic Neuron Differentiation Respiratory Basal Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere	Estrogen-dependent gene expression Formation of axial mesoderm
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergy ( 27182965) Chromium levels ( 26025379) Coronary artery aneurysm in Kawasaki disease ( 26434682) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Intraocular pressure ( 29617998) Periodontitis (CDC/AAP) ( 24024966) Self-reported allergy ( 23817569) Tonsillectomy ( 27182965 28928442)
Interacting Genes		195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516	6 interacting genes: AR H3-4 NKX2-1 ONECUT1 SEZ6L2 TLE1
Entrez ID		8290	3169
HPRD ID		04156	03801
Ensembl ID		ENSG00000168148	ENSG00000129514
Uniprot IDs		Q16695	P55317
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50	7VOX 8VFY 8VFZ 8VG1 8VG2
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region	Leydig Cell Differentiation Developmental Induction Endoderm Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Epithelial Cell Differentiation Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Pancreatic D Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Globus Pallidus Development Club Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Spermatogonial Cell Division Androgen Binding DNA-binding Transcription Factor Activity Pancreatic A Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Cell Fate Commitment RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Prostatic Bud Formation Locomotory Behavior Lung Saccule Development RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Type II Pneumocyte Differentiation DNA Replication-dependent Chromatin Assembly Forebrain Neuron Fate Commitment Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Type B Pancreatic Cell Differentiation Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Regulator Complex Estrogen Response Element Binding Cerebellar Purkinje Cell Layer Development Transcription Cis-regulatory Region Binding Genitalia Morphogenesis
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