IRAK1 and HSP90AA1

Number of citations of the paper that reports this interaction (PMID 15647277)
10

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		IRAK1	HSP90AA1
Gene Name		interleukin-1 receptor-associated kinase 1	heat shock protein 90kDa alpha (cytosolic), class A member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Melanosome Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Ubiquitin-protein Transferase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Heat Shock Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Nucleotide Binding Protein Binding ATP Binding ATPase Activity MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Identical Protein Binding Protein Homodimerization Activity Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Aging Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Hypoxia	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitochondrial Transport Receptor-mediated Endocytosis Response To Unfolded Protein Organelle Organization Signal Transduction Axon Guidance Cellular Response To Heat Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Refolding Small Molecule Metabolic Process Protein Import Into Mitochondrial Outer Membrane Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Chaperone-mediated Protein Complex Assembly Regulation Of Cellular Response To Heat
Pathways		NF-kB is activated and signals survival p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	HSF1 activation Regulatory RNA pathways Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition Influenza Life Cycle Influenza Viral RNA Transcription and Replication Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Uptake and actions of bacterial toxins EPH-Ephrin signaling Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Fcgamma receptor (FCGR) dependent phagocytosis Recruitment of mitotic centrosome proteins and complexes Regulation of actin dynamics for phagocytic cup formation vRNP Assembly Influenza Infection Signaling by ERBB2 Signaling by VEGF Signaling by EGFR in Cancer Sema3A PAK dependent Axon repulsion Mitotic G2-G2/M phases Uptake and function of diphtheria toxin PIWI-interacting RNA (piRNA) biogenesis Organelle biogenesis and maintenance Axon guidance Attenuation phase G2/M Transition VEGFA-VEGFR2 Pathway HSF1-dependent transactivation EPHA-mediated growth cone collapse Metabolism of nitric oxide VEGFR2 mediated vascular permeability Loss of Nlp from mitotic centrosomes Scavenging by Class F Receptors eNOS activation and regulation Innate Immune System Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer Assembly of the primary cilium Cellular response to heat stress Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic eNOS activation Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation Constitutive Signaling by EGFRvIII
Drugs			Rifabutin Nedocromil 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Geldanamycin 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid 17-Dmag 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine Adenosine-5\'-Diphosphate 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		49 interactors: AKT1 BCL10 BTK CCDC47 FADD HIST3H3 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 PELI1 PELI2 PELI3 PPP3CB PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 SUMO1 TAB2 TICAM2 TIFA TIRAP TLR2 TLR4 TMEM173 TOLLIP TRAF4 TRAF6 TRIM32 UNC93B1 YTHDC2	130 interactors: AHR AHSA1 AHSA2 AIP AIPL1 AKT1 AKT2 APAF1 APOB AR ARNTL ASGR1 BIRC5 BRMS1 CALM1 CDC37 CDC37L1 CDK5R1 CDKN2A CERS2 CFTR CHEK1 CHUK CKS1B CKS2 CRNKL1 CSNK2A1 CSNK2A2 DAP3 DNAJC7 EIF2AK1 EIF2AK2 EIF2AK3 EPAS1 EPRS ERBB2 ERN1 ESR1 FAM162A FANCA FANCC FKBP4 FKBP5 FKBP6 FYN GNA12 GSK3B GUCY1B3 GZMA HDAC6 HIF1A HIF3A HSPA1A HSPA8 IKBKB IKBKE IKBKG IP6K2 IRAK1 IRF3 JUN KDR LCK LSM1 MAP3K14 MAP3K3 MAPK1 MCF2 MIS12 MMP2 MS4A2 MTRNR2L1 MYC MYOD1 NDRG1 NOS1 NOS3 NPAS2 NR2C2 NR3C1 NR3C2 NSL1 PAK1 PDPK1 PIM1 PMF1 PPARA PPARD PPID PPIL2 PPP5C PRKCA PRKCD PRKDC PTGDS PTGES3 RAF1 RIPK1 RPS3 RPS3A RUNX1T1 SGTA SIM1 SKP1 SLC2A4 SLC34A1 SMYD2 SMYD3 SNCA SRC ST13 STARD13 STAT3 STIP1 STUB1 SUGT1 SVIL TBK1 TERT TJP1 TNFRSF1A TOMM34 TOMM40 TOMM70A TP53 UBE2N UCHL1 USP19 USP50 WASL
Entrez ID		3654	3320
HPRD ID		02235	00777
Ensembl ID		ENSG00000184216	ENSG00000080824
Uniprot IDs		D3YTB5 P51617	K9JA46 P07900 Q86SX1
PDB IDs			1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 4AIF 4AWO 4AWP 4AWQ 4B7P 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Defense Response Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Toll-like Receptor 9 Signaling Pathway Response To Stress I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 5 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 10 Signaling Pathway Signaling Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Signal Transduction Response To Biotic Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Response To Other Organism Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Cellular Response To Stimulus Response To Stress Regulation Of Cell Death Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Metabolic Process Response To Abiotic Stimulus Cellular Metabolic Process Regulation Of Apoptotic Process Cell Death Positive Regulation Of Signal Transduction Death Regulation Of Signaling Cellular Response To Stress Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Catalytic Activity Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Signal Transduction Signaling Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Regulation Of Gene Expression Response To External Stimulus Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Phosphorylation Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable	alphascreen ammp calnexin cndp2 combines hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp
Tagcloud (Difference) ?		auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable	alphascreen ammp calnexin cndp2 combines hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp
Tagcloud (Intersection) ?