H3-4 and BPTF

Number of citations of the paper that reports this interaction (PubMedID 20850016)
0

Data Source:
BioGRID (unspecified method)

		H3-4	BPTF
Description		H3.4 histone, cluster member	bromodomain PHD finger transcription factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm NURF Complex Dendrite Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome ATPase Complex
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Embryonic Placenta Development Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Endoderm Development Anterior/posterior Pattern Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Nerve Growth Factor Stimulus
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Alcohol dependence symptom count ( 27151647) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) EGFR mutation-positive lung adenocarcinoma ( 27501781) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hand grip strength ( 29691431) HDL cholesterol ( 30275531) Height ( 31562340) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Lung adenocarcinoma ( 22797724) Lung cancer ( 23143601) Macular thickness ( 30535121) Metabolic syndrome ( 31589552) Neutrophil percentage of granulocytes ( 27863252) Non-small cell lung cancer ( 31326317) Psoriasis ( 25854761) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 32154731 32203549 33339817) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516	10 interacting genes: H3-3A H3-4 H4C9 KEAP1 MAZ NFE2L2 SMAD2 SMAD3 SQSTM1 SUMO2
Entrez ID		8290	2186
HPRD ID		04156	03490
Ensembl ID		ENSG00000168148	ENSG00000171634
Uniprot IDs		Q16695	J3QQK4 Q12830
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50	2F6J 2F6N 2FSA 2FUI 2FUU 2RI7 3QZS 3QZT 3QZV 3UV2 5H6Y 5R4G 5R4H 5R4I 5R4J 5R4K 5R4L 5R4M 5R4N 5R4O 6AZE 6LU5 6LU6 7DMY 7DN4 7F5D 7F5E 7JT4 7K6R 7K6S 7KDW 7KDZ 7LP0 7LPK 7LRK 7LRO 7M2E 7RWN 7RWO 7RWP 7RWQ 7VD4 8AG2 8F6G 8OU2
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region	Ubiquitin Protein Ligase Binding Paraxial Mesoderm Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mesoderm Morphogenesis SMAD Protein Complex Pericardium Development Trophoblast Cell Migration Heteromeric SMAD Protein Complex Nucleoplasm Structural Constituent Of Chromatin Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Nucleosome Assembly DNA Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Ferroptosis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ferroptosis Positive Regulation Of Proteasomal Protein Catabolic Process I-SMAD Binding Nucleosome Regulation Of Protein Catabolic Process Nucleus Nucleosome Organization Inclusion Body Positive Regulation Of Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Regulation Of Cell Differentiation Response To Angiotensin Regulation Of Transcription By RNA Polymerase II Disordered Domain Specific Binding R-SMAD Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromosome, Telomeric Region Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Response To Oxidative Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-DNA Complex Assembly Endoderm Development MiRNA Processing Positive Regulation Of RNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process
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