H3-4 and PARP2

Number of citations of the paper that reports this interaction (PubMedID 28190768)
48

Data Source:
BioGRID (enzymatic study)

		H3-4	PARP2
Description		H3.4 histone, cluster member	poly(ADP-ribose) polymerase 2
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Site Of DNA Damage
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Chromatin Binding Damaged DNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Nucleosome Binding Poly-ADP-D-ribose Binding NAD DNA ADP-ribosyltransferase Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity Poly-ADP-D-ribose Modification-dependent Protein Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation	DNA Repair Base-excision Repair Double-strand Break Repair DNA Damage Response DNA ADP-ribosylation Decidualization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Response To Oxygen-glucose Deprivation Extrinsic Apoptotic Signaling Pathway Hippocampal Neuron Apoptotic Process DNA Repair-dependent Chromatin Remodeling
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere	POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516	14 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 UBC XRCC1
Entrez ID		8290	10038
HPRD ID		04156	09660
Ensembl ID		ENSG00000168148	ENSG00000129484
Uniprot IDs		Q16695	Q9UGN5
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50	3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N 7AEO 7R59 8HE8 8HKN 8HKO 8HKS 8HLJ 8HLQ 8JNY
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region	Chromosome Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Chromatin Remodeling Nucleosome Organization Chromatin Organization Chromosome Organization Protein-DNA Complex Assembly Negative Regulation Of Chromosome Organization Nucleus Nucleoplasm Protein Localization To Chromosome Telomere Organization Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Nucleosomal DNA Binding Site Of DNA Damage Protein Heterodimerization Activity DNA Binding Chromosome, Centromeric Region Protein Localization To Chromatin Regulation Of Protein ADP-ribosylation Chromosome, Telomeric Region Poly-ADP-D-ribose Binding Protein-containing Complex Assembly Regulation Of Chromosome Organization Protein-containing Complex Organization Protein Poly-ADP-ribosylation Condensed Chromosome, Centromeric Region Chromatin DNA Repair-dependent Chromatin Remodeling Regulation Of DNA Recombination Cellular Component Assembly Pericentric Heterochromatin Regulation Of Necroptotic Process Organelle Organization Nucleosome Binding Negative Regulation Of Telomere Maintenance Regulation Of Programmed Necrotic Cell Death Chromosome Condensation Protein Localization To Chromosome, Centromeric Region Chromatin Binding Regulation Of DNA Metabolic Process Macrophage Differentiation Double-strand Break Repair NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity
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