HIST3H3 and MTA1

Number of citations of the paper that reports this interaction (PMID 23281010)
0

Data Source:
BioGRID (unspecified method)

		HIST3H3	MTA1
Gene Name		histone cluster 3, H3	metastasis associated 1
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Microtubule NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding
	Biological Process	Telomere Maintenance	Double-strand Break Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Response To Ionizing Radiation Response To Lipopolysaccharide Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Regulation Of Inflammatory Response Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-Protein Interactions		183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516	34 interactors: BLOC1S1 CCNH CSNK1G2 DDX18 DYNLL1 ESR1 GPR183 GRB2 HDAC1 HDAC2 HIF1A HIST3H3 IKZF1 ITGB3BP JUN KHDRBS2 KPNA3 KRT40 KRTAP10-8 LMO4 LZTS2 MAGEA11 MBD3 MBD3L2 MNAT1 NACC2 NELFCD NOTCH2NL RBBP4 SAT1 SH3GL1 SH3GLB1 TP53 UBE2I
Entrez ID		8290	9112
HPRD ID		04156	04633
Ensembl ID		ENSG00000168148	ENSG00000182979
Uniprot IDs		Q16695	Q13330 Q9BRL8
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R	4BKX
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Viral Process ATP-dependent Chromatin Remodeling Regulation Of Viral Transcription RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Regulation Of Gene Expression, Epigenetic Macromolecule Biosynthetic Process Positive Regulation Of Receptor Biosynthetic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Mitotic Cell Cycle Process Regulation Of Viral Process Multicellular Organismal Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Viral Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Complex Assembly Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic nucleosome nurd nurf55 overlaps pair phf6 pocket propeller rbbp4 recognizing remodeling repression su top
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic nucleosome nurd nurf55 overlaps pair phf6 pocket propeller rbbp4 recognizing remodeling repression su top
Tagcloud (Intersection) ?