H3-4 and ERAP1

Number of citations of the paper that reports this interaction (PubMedID 23281010)
30

Data Source:
BioGRID (unspecified method)

		H3-4	ERAP1
Description		H3.4 histone, cluster member	endoplasmic reticulum aminopeptidase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Endopeptidase Activity Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation	Angiogenesis Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Assembly With MHC Class I Protein Complex Proteolysis Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS			Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Alcohol dependence ( 19581569) Ankylosing spondylitis ( 20062062 30946743 23749187 21743469) Behcet's disease ( 23291587) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576) Body mass index ( 26426971 29273807) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Medication use (calcium channel blockers) ( 31015401) Psoriasis ( 20953190 25854761 25574825 23143594) Psoriasis vulgaris ( 26626624) Systolic blood pressure ( 30578418) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516	4 interacting genes: H3-4 IL6R TNFRSF1A WEE2-AS1
Entrez ID		8290	51752
HPRD ID		04156	06015
Ensembl ID		ENSG00000168148	ENSG00000164307
Uniprot IDs		Q16695	A0A075BTL2 Q9NZ08
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50	2YD0 3MDJ 3QNF 3RJO 5J5E 6M8P 6MGQ 6Q4R 6RQX 6RYF 6T6R 7MWB 7MWC 7Z28 9GJN 9GJS 9GK6 9GKE
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region	Extrinsic Apoptotic Signaling Pathway Ciliary Neurotrophic Factor Receptor Activity Hepatic Immune Response Receptor Complex Ciliary Neurotrophic Factor Binding Interleukin-6 Receptor Complex Interleukin-11 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Binding Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Spermatogonial Cell Division Pre-mRNA 5'-splice Site Binding Interleukin-11-mediated Signaling Pathway Defense Response To Bacterium Interleukin-6 Receptor Binding Positive Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development DNA Replication-dependent Chromatin Assembly MRNA 5'-splice Site Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet Aggregation Regulation Of Cell Differentiation Negative Regulation Of Collagen Biosynthetic Process Cytokine-mediated Signaling Pathway Response To Bacterium T-helper 17 Cell Lineage Commitment Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Endocrine Pancreas Development Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Homotypic Cell-cell Adhesion U1 SnRNP Regulation Of Membrane Lipid Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment
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