IRAK1 and NLRP12

Number of citations of the paper that reports this interaction (PubMedID 16203735)
53

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IRAK1	NLRP12
Description		interleukin 1 receptor associated kinase 1	NLR family pyrin domain containing 12
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Binding ATP Binding Protein-macromolecule Adaptor Activity Cysteine-type Endopeptidase Activator Activity
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Negative Regulation Of Cytokine Production Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Dendritic Cell Migration Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Fostamatinib
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)	Fasting glucose ( 33381925) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Testicular germ cell tumor ( 28604728)
Interacting Genes		52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2	3 interacting genes: FAF1 IRAK1 PYCARD
Entrez ID		3654	91662
HPRD ID		02235	14803
Ensembl ID		ENSG00000184216	ENSG00000142405
Uniprot IDs		D3YTB5 P51617	P59046
PDB IDs		6BFN	2L6A 4XHS 5H7N
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication	Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Heat Shock Protein Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Interleukin-1 Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Myosin I Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Ooplasm Fas Signaling Pathway AIM2 Inflammasome Complex Myeloid Dendritic Cell Activation Involved In Immune Response Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Stress Toll Signaling Pathway Positive Regulation Of Cell-cell Adhesion Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Positive Regulation Of Cell Communication Positive Regulation Of Innate Immune Response Positive Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Interleukin-6 Receptor Binding IkappaB Kinase Complex Macropinocytosis Immune Response-activating Signaling Pathway Interleukin-33-mediated Signaling Pathway Osmosensory Signaling Pathway
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