IRAK1 and TLR2

Number of citations of the paper that reports this interaction (PMID 10395652)
28

Data Source:
HPRD (in vivo)

		IRAK1	TLR2
Gene Name		interleukin-1 receptor-associated kinase 1	toll-like receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Cell Projection Cell Body
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Ubiquitin-protein Transferase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Heat Shock Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Signaling Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Diacyl Lipopeptide Binding Peptidoglycan Binding Protein Heterodimerization Activity Lipoteichoic Acid Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Aging Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Hypoxia	Response To Hypoxia Microglial Cell Activation Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin Positive Regulation Of Leukocyte Migration Cell Surface Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Chloramphenicol Transport Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Induction By Symbiont Of Defense-related Host Nitric Oxide Production Positive Regulation Of Macrophage Cytokine Production Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		NF-kB is activated and signals survival p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Beta defensins MyD88:Mal cascade initiated on plasma membrane Defensins Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs			OspA lipoprotein S-(Dimethylarsenic)Cysteine
Diseases
GWAS
Protein-Protein Interactions		49 interactors: AKT1 BCL10 BTK CCDC47 FADD HIST3H3 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 PELI1 PELI2 PELI3 PPP3CB PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 SUMO1 TAB2 TICAM2 TIFA TIRAP TLR2 TLR4 TMEM173 TOLLIP TRAF4 TRAF6 TRIM32 UNC93B1 YTHDC2	18 interactors: CD14 HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6
Entrez ID		3654	7097
HPRD ID		02235	04323
Ensembl ID		ENSG00000184216
Uniprot IDs		D3YTB5 P51617	B3KWR9 O60603
PDB IDs			1FYW 1FYX 1O77 2Z7X 2Z80
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Defense Response Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Toll-like Receptor 9 Signaling Pathway Response To Stress I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 5 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 10 Signaling Pathway Signaling Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Signal Transduction Response To Biotic Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Response To Other Organism Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway	Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Response To Molecule Of Bacterial Origin Intracellular Signal Transduction Regulation Of Cytokine Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Signal Transduction Response To External Stimulus Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Signaling Cell Communication Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Other Organism
Tagcloud ?		auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated
Tagcloud (Difference) ?		auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated
Tagcloud (Intersection) ?