IRAK1 and YTHDC2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRAK1	YTHDC2
Gene Name		interleukin-1 receptor-associated kinase 1	YTH domain containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex	Nucleus Endoplasmic Reticulum
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Ubiquitin-protein Transferase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Heat Shock Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	ATP-dependent RNA Helicase Activity Protein Binding ATP Binding RNA-dependent ATPase Activity Poly(A) RNA Binding RNA Polymerase Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Aging Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Hypoxia	RNA Processing Response To Tumor Necrosis Factor Positive Regulation By Host Of Viral Genome Replication Response To Interleukin-1
Pathways		NF-kB is activated and signals survival p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			F-cell distribution ( 21326311)
Protein-Protein Interactions		49 interactors: AKT1 BCL10 BTK CCDC47 FADD HIST3H3 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 PELI1 PELI2 PELI3 PPP3CB PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 SUMO1 TAB2 TICAM2 TIFA TIRAP TLR2 TLR4 TMEM173 TOLLIP TRAF4 TRAF6 TRIM32 UNC93B1 YTHDC2	2 interactors: IRAK1 IRF4
Entrez ID		3654	64848
HPRD ID		02235	11690
Ensembl ID		ENSG00000184216	ENSG00000047188
Uniprot IDs		D3YTB5 P51617	Q9H6S0
PDB IDs			2YU6
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Defense Response Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Toll-like Receptor 9 Signaling Pathway Response To Stress I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 5 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 10 Signaling Pathway Signaling Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Signal Transduction Response To Biotic Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Response To Other Organism Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway	Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Cytokine-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment T-helper 17 Cell Differentiation Cellular Response To Cytokine Stimulus Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Peptidoglycan Innate Immune Response T-helper Cell Lineage Commitment Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Production CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Immune Response Interleukin-1-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-2 Biosynthetic Process T Cell Lineage Commitment Myeloid Dendritic Cell Differentiation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway Response To Protozoan Myeloid Dendritic Cell Activation Positive T Cell Selection T-helper Cell Differentiation Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Interleukin-10 Production Regulation Of Interleukin-4 Production Positive Regulation Of Protein Metabolic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Production Immune Response Regulation Of Immune System Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Defense Response Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Dendritic Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling CD4-positive, Alpha-beta T Cell Activation Regulation Of NIK/NF-kappaB Signaling
Tagcloud ?		auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable	atf cahl collectively cre csa cyclophilin cyclosporin downregulated facilitates hcc hcv hdac helicase hepatitis hepatocellular hepatocyte hepatocytes huh7 identical interference jun next ns5b transcribed trichostatin trimer tsa untreated
Tagcloud (Difference) ?		auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable	atf cahl collectively cre csa cyclophilin cyclosporin downregulated facilitates hcc hcv hdac helicase hepatitis hepatocellular hepatocyte hepatocytes huh7 identical interference jun next ns5b transcribed trichostatin trimer tsa untreated
Tagcloud (Intersection) ?