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IRAK1 and TRAF4
Number of citations of the paper that reports this interaction (PubMedID
16052631
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
IRAK1
TRAF4
Description
interleukin 1 receptor associated kinase 1
TNF receptor associated factor 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Protein-containing Complex
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Bicellular Tight Junction
Membrane
Perinuclear Region Of Cytoplasm
Anchoring Junction
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Biological Process
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Toll Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon-mediated Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Immune System Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Respiratory Gaseous Exchange By Respiratory System
Respiratory Tube Development
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Celiac disease (
22057235
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
32723749
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
19838195
26502338
26606652
26663301
33272962
)
Interacting Genes
52 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP1CC
PPP3CB
PRDX1
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TBKBP1
TICAM2
TIFA
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
USP20
YTHDC2
137 interacting genes:
ABI3
ACTMAP
ALKBH4
ANXA1
AR
ATOSB
ATOX1
BACH2
BAHD1
BANP
BCKDK
BCL6B
BEGAIN
BEX3
BYSL
CALCOCO2
CAV1
CBL
CBLC
CCHCR1
CENPE
CEP85
CHEK1
CHUK
DISC1
DNM2
DPEP2NB
DTX3
EXOC7
EYA2
EZHIP
FAM90A1
FAT1
FBXL18
FRS3
FTH1
GOLGA2
GOLGA6A
GOLGA6L9
GORASP1
GORASP2
GPRASP1
HEY2
HGS
HMG20A
HOMEZ
HOXA1
HOXB5
IRAK1
IRS1
ISYNA1
KANK2
KANSL1
KDM1A
KRT31
KRT36
LENG8
LNX1
LTBR
MAGEC2
MAGED1
MAP3K4
MRPL28
NCF1
NGFR
NHERF2
NOS1AP
NPAS2
NTRK1
NUDT16L1
OGT
PCSK5
PDE4DIP
PHLDA1
PICK1
PKD1P1
PLAGL2
PLEKHA7
PLSCR1
POLR2J
POLR2J3
PSMC3
QARS1
RAD54L2
RBPMS
REXO1L6P
RNF114
RNF144B
RNF4
RPS6KB1
SF3B4
SIGLEC7
SMURF1
SMURF2
SNRPB
SORBS2
SPDL1
SUMO1
TARBP2
TAX1BP1
TBC1D7
TBC1D8
TFAP4
TGFB1I1
TICAM1
TNFRSF4
TP53BP2
TRAF6
TRIM27
TRIM37
TSGA10IP
TYK2
UBC
UBE2D1
UBE2I
UBL4A
UBL4B
USP7
VPS52
WBP11
WWP1
WWP2
ZBTB16
ZBTB26
ZC3H12C
ZMYM5
ZNF177
ZNF275
ZNF3
ZNF512B
ZNF559-ZNF177
ZNF581
ZNF620
ZNF688
ZNF784
ZNF835
ZRANB1
Entrez ID
3654
9618
HPRD ID
02235
03915
Ensembl ID
ENSG00000184216
ENSG00000076604
Uniprot IDs
D3YTB5
P51617
Q9BUZ4
PDB IDs
6BFN
2EOD
2YUC
3ZJB
4K8U
4M4E
5YC1
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Immune System Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Innate Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Innate Immune Response
Response To External Biotic Stimulus
Cell Surface Toll-like Receptor Signaling Pathway
Response To Other Organism
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Activation Of Immune Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Lipopolysaccharide-mediated Signaling Pathway
Immune Response
Regulation Of Intracellular Signal Transduction
Defense Response To Symbiont
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of Immune System Process
Regulation Of Cytokine Production
Signal Transduction
Intracellular Signaling Cassette
Signaling Adaptor Activity
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Protein Binding
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cytosol
Protein Modification By Small Protein Conjugation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Ubiquitination
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-protein Transferase Activity
Regulation Of Gene Expression
Ubiquitin Protein Ligase Activity
Post-translational Protein Modification
Negative Regulation Of RNA Metabolic Process
Modification-dependent Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Toll-like Receptor Signaling Pathway
Identical Protein Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Metabolic Process
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Cytoplasm
Positive Regulation Of Metabolic Process
Regulation Of Protein Modification Process
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
PML Body
Regulation Of Programmed Cell Death
Negative Regulation Of Macromolecule Biosynthetic Process
Signaling Adaptor Activity
Zinc Ion Binding
Proteolysis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
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