H3-4 and PARP1

Number of citations of the paper that reports this interaction (PubMedID 28190768)
48

Data Source:
BioGRID (enzymatic study)

		H3-4	PARP1
Description		H3.4 histone, cluster member	poly(ADP-ribose) polymerase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Heterochromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Extracellular Exosome	Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Nuclear Replication Fork Site Of DNA Damage
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Chromatin Binding Damaged DNA Binding RNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Nucleosome Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Transcription Regulator Activator Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Regulation Of Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Immune System Process DNA Repair Double-strand Break Repair Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Carbohydrate Biosynthetic Process Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Mitochondrial DNA Repair Innate Immune Response Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Necroptotic Process Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Cellular Response To Zinc Ion Cellular Response To Transforming Growth Factor Beta Stimulus Replication Fork Reversal DNA Repair-dependent Chromatin Remodeling Negative Regulation Of CGAS/STING Signaling Pathway Transcription Pausing By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen-containing Compound Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Aldosterone Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Regulation Of Base-excision Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Site Of Double-strand Break ATP Generation From Poly-ADP-D-ribose Negative Regulation Of ATP Biosynthetic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Meiotic recombination Inhibition of DNA recombination at telomere	POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785 32109421) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480 32341527) Platelet count ( 29403010) Telomere length ( 29151059)
Interacting Genes		195 interacting genes: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BACC1 BIRC5 BMI1 BPTF BRD7 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK COPRS CREBBP CTBP1 CTBP2 DCAF1 DEK DNMT1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EMSY EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPL HNRNPR HPF1 ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM1B KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2C KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 MYB NAP1L4 NASP NBN NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 NSD2 ORC2 ORC3 ORC4 ORC5 PARP1 PARP2 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PHRF1 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRMT5 PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RIPPLY1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SGF29 SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TCF19 TDRD3 TNPO1 TRPM7 UHRF1 WDR5 ZMYM4 ZMYND11 ZNF217 ZNF516	123 interacting genes: AATF ANXA1 APTX ATM ATR BCL2 BGLT3 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CEBPA CENPA CENPB CTCF CTSB CTSG DTX2 DUX4 E2F1 E4F1 EPB41L2 ERBB2 ERCC6 ERG ETS1 FNDC3B FOXO1 GTF2F1 GZMB GZMM H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-4 H4C3 HDAC1 HDAC3 HECTD3 HIPK2 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LINC00624 LZTR1 MACROH2A1 MALAT1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 NUDT16 OGT OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF10 RNF144A RNF168 RNF4 RPS3A RSPH1 RXRA SENP1 SENP3 SMURF2 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 TP53BP1 TRIP12 UBE2I USP1 USP15 USP7 WEE2-AS1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		8290	142
HPRD ID		04156	01435
Ensembl ID		ENSG00000168148	ENSG00000143799
Uniprot IDs		Q16695	P09874
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R 4V2V 4V2W 6OIE 6WAT 6WAU 8VMI 8Z50	1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6M3I 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW 7AAA 7AAB 7AAC 7AAD 7CMW 7KK2 7KK3 7KK4 7KK5 7KK6 7ONR 7ONS 7ONT 7S68 7S6H 7S6M 7S81 7SCY 7SCZ 8FYY 8FYZ 8FZ1 8G0H 8HE7 8HLR 8JNZ 8U4W 9BPY 9CKC 9DMC 9ETQ 9ETR
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Transcription Factor TFIID Complex Chromosome Protein-DNA Complex Assembly Nucleic Acid Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFTC Complex Negative Regulation Of Gene Expression, Epigenetic SAGA Complex MRNA Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress RNA Polymerase II Preinitiation Complex Assembly Transcription Coactivator Activity Chromosome, Telomeric Region	Nucleoplasm Nucleus DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Chromosome Protein Modification Process Negative Regulation Of DNA Metabolic Process DNA Repair DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Chromatin Cellular Response To Stress Post-translational Protein Modification Negative Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Negative Regulation Of Cell Cycle Protein Localization To Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Transcription Regulator Complex
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