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H3-4 and PHF7
Number of citations of the paper that reports this interaction (PubMedID
22595675
)
62
Data Source:
BioGRID
(unspecified method)
H3-4
PHF7
Description
H3.4 histone, cluster member
PHD finger protein 7
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Heterochromatin
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Chromosome
Extracellular Exosome
Nucleus
Nucleoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Nuclear Speck
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Biological Process
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Chromatin Assembly
Spermatogonial Cell Division
Regulation Of Cell Differentiation
Negative Regulation Of Osteoclast Proliferation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Triglyceride levels (
32154731
)
Interacting Genes
195 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BACC1
BIRC5
BMI1
BPTF
BRD7
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
18 interacting genes:
APP
ARIH2
DTX3L
FBXL17
H3-4
IKBKG
MAGEF1
MDM2
RNF111
RNF14
RNF34
SRPK1
TRIM26
TRIM41
UBE2D2
UBE2D4
USP1
USP15
Entrez ID
8290
51533
HPRD ID
04156
15127
Ensembl ID
ENSG00000168148
ENSG00000010318
Uniprot IDs
Q16695
A0A024R336
A8K856
Q9BWX1
PDB IDs
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
8VMI
8Z50
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Remodeling
Nucleoplasm
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Chromatin Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Epigenetic Regulation Of Gene Expression
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Histone Binding
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Chromatin
Positive Regulation Of Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Transcription Factor TFIID Complex
Chromosome
Protein-DNA Complex Assembly
Nucleic Acid Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Transcription Factor TFTC Complex
Negative Regulation Of Gene Expression, Epigenetic
SAGA Complex
MRNA Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
RNA Polymerase II Preinitiation Complex Assembly
Transcription Coactivator Activity
Chromosome, Telomeric Region
Post-translational Protein Modification
Protein Ubiquitination
Protein Polyubiquitination
Protein Modification Process
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Protein Ligase Activity
Protein Metabolic Process
Macromolecule Catabolic Process
Nucleus
Protein K48-linked Ubiquitination
Macromolecule Metabolic Process
Ubiquitin-protein Transferase Activity
Transferase Activity
Catabolic Process
Nucleoplasm
Innate Immune Response
Defense Response To Symbiont
Defense Response To Other Organism
Regulation Of Cellular Response To Stress
Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
Response To Virus
Regulation Of Signal Transduction
Protein Autoubiquitination
Zinc Ion Binding
Response To Stress
Response To Other Organism
Protein-containing Complex
Proteasomal Protein Catabolic Process
Immune Response
Regulation Of Cell Communication
Regulation Of Signaling
Defense Response To Virus
Ubiquitin Ligase Complex
Response To External Biotic Stimulus
Intracellular Signal Transduction
Regulation Of Signal Transduction By P53 Class Mediator
Defense Response
Immune System Process
Protein K6-linked Ubiquitination
Protein Catabolic Process
Amyloid Fibril Formation
Cytosol
Ubiquitin Conjugating Enzyme Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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