HIST3H3 and SMYD3

Number of citations of the paper that reports this interaction (PMID 15235609)
97

Data Source:
BioGRID (enzymatic study)

		HIST3H3	SMYD3
Gene Name		histone cluster 3, H3	SET and MYND domain containing 3
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Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Telomere Maintenance	Chromatin Organization Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Dexamethasone Stimulus
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516	16 interactors: APP CAMK2B CYP39A1 EED EZH2 H3F3C HELZ HIST3H3 HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K TRIT1 VANGL1 ZNF557
Entrez ID		8290	64754
HPRD ID		04156	12297
Ensembl ID		ENSG00000168148	ENSG00000185420
Uniprot IDs		Q16695	B3KN46 Q9H7B4
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R	3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression	Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Inhibitory G-protein Coupled Receptor Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Activation Of Meiosis Involved In Egg Activation Innate Immune Response Regulation Of Synapse Structure Or Activity Cellular Metabolic Process Bile Acid Catabolic Process Collateral Sprouting In Absence Of Injury Response To Heat Transcription, DNA-templated Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Protein Import Into Mitochondrial Outer Membrane Activation Of Meiosis Cholesterol Metabolic Process Histone Methylation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Protein Lipoylation Sterol Metabolic Process Neuromuscular Process Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Synaptic Transmission, Cholinergic Axon Choice Point Recognition
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Intersection) ?