DNMT3L and HIST2H2AC

Number of citations of the paper that reports this interaction (PMID 17687327)
307

Data Source:
BioGRID (pull down)

		DNMT3L	HIST2H2AC
Gene Name		DNA (cytosine-5-)-methyltransferase 3-like	histone cluster 2, H2ac
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated	Biological_process
Pathways		Epigenetic regulation of gene expression DNA methylation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: DNMT3A DNMT3B GSK3B HDAC1 HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A NUDT21 PHPT1 RSL24D1	65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46
Entrez ID		29947	8338
HPRD ID		09417	09107
Ensembl ID		ENSG00000142182	ENSG00000184260
Uniprot IDs		Q9UJW3	Q16777
PDB IDs		2PV0 2PVC 2QRV
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Silencing DNA Methylation DNA Modification Gene Silencing Regulation Of Gene Expression By Genetic Imprinting Genetic Imprinting S-adenosylmethioninamine Metabolic Process Hypermethylation Of CpG Island DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Methylation-dependent Chromatin Silencing Chromatin Organization Negative Regulation Of Biosynthetic Process Chromatin Silencing At RDNA Methylation Regulation Of DNA Methylation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Amino Acid Stimulus ATP-dependent Chromatin Remodeling Peptidyl-histidine Dephosphorylation Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development DNA Metabolic Process Response To Amino Acid Re-entry Into Mitotic Cell Cycle Histone H4-K20 Demethylation Negative Regulation Of ATP Citrate Synthase Activity Negative Regulation Of Neuron Maturation Nucleosome Assembly Nucleobase-containing Compound Metabolic Process Chromatin Assembly Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Nucleosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Megakaryocyte Differentiation Cellular Response To Interleukin-3 Protein-DNA Complex Assembly	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly
Tagcloud ?		add adds atrx autoinhibition autoinhibitory catalytically connection disrupts embryogenesis enzymatic h3k4 h3k4me0 h3k4me3 imprinting inheritance methyltransferase methyltransferases novo paralogue positioning recognizes releases stimulates tail unexpected unmethylated
Tagcloud (Difference) ?		add adds atrx autoinhibition autoinhibitory catalytically connection disrupts embryogenesis enzymatic h3k4 h3k4me0 h3k4me3 imprinting inheritance methyltransferase methyltransferases novo paralogue positioning recognizes releases stimulates tail unexpected unmethylated
Tagcloud (Intersection) ?