DNMT3L and MECP2

Number of citations of the paper that reports this interaction (PubMedID 24952347)
0

Data Source:
BioGRID (pull down)

		DNMT3L	MECP2
Description		DNA methyltransferase 3 like	methyl-CpG binding protein 2
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GO Annotations	Cellular Component	Heterochromatin Condensed Nuclear Chromosome Nucleus Cytoplasm Cytosol ESC/E(Z) Complex Catalytic Complex	Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Synapse Postsynapse
	Molecular Function	Protein Binding Enzyme Activator Activity Zinc Ion Binding Enzyme Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding SiRNA Binding Molecular Adaptor Activity Histone Reader Activity Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding
	Biological Process	Placenta Development DNA Methylation-dependent Constitutive Heterochromatin Formation Male Meiosis I Spermatogenesis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Epigenetic Programing Of Female Pronucleus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Chorionic Trophoblast Cell Differentiation Genomic Imprinting Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inositol Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutamine Metabolic Process Biogenic Amine Metabolic Process Notch Signaling Pathway Chemical Synaptic Transmission Synapse Assembly Brain Development Respiratory Gaseous Exchange By Respiratory System Learning Memory Long-term Memory Intracellular Protein Localization Glucocorticoid Metabolic Process Cell Population Proliferation Associative Learning Adult Locomotory Behavior Visual Learning Post-embryonic Development Gene Expression Regulation Of Gene Expression Negative Regulation Of Gene Expression Glial Cell Proliferation Dendrite Development Negative Regulation Of Angiogenesis Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Neuron Differentiation Neuron Projection Development Heterochromatin Formation Cardiolipin Metabolic Process Multicellular Organismal Response To Stress Social Behavior Epigenetic Regulation Of Gene Expression Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylcholine Metabolic Process Regulation Of Synaptic Plasticity Cell Development Catecholamine Secretion Neuromuscular Process Controlling Posture Neuromuscular Process Negative Regulation Of Developmental Process Negative Regulation Of Smooth Muscle Cell Differentiation Response To Other Organism Excitatory Postsynaptic Potential Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Genomic Imprinting Positive Regulation Of Microtubule Nucleation Trans-synaptic Signaling By BDNF Regulation Of Multicellular Organismal Development
Pathways		DNA methylation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases			Non-syndromic X-linked mental retardation Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS) Rett syndrome
GWAS			Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 19838195 26502338 26663301)
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	17 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HIPK2 HMGB1 NCOR1 PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1
Entrez ID		29947	4204
HPRD ID		09417	02050
Ensembl ID		ENSG00000142182	ENSG00000169057
Uniprot IDs		Q9UJW3	A0A140VKC4 D3YJ43 P51608 Q59FJ6
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J 7X9D 8TCI 8XEE	1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK 6YWW 8AJR 8ALQ
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-templated Transcription Positive Regulation Of MiRNA Transcription Cellular Developmental Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Nucleoplasm Regulation Of RNA Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic DNA Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Germ Cell Nucleus Regulation Of Nucleotide-excision Repair Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Binding Positive Regulation Of Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Cellular Developmental Process Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Leukocyte Differentiation
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