DNMT3L and NR6A1

Number of citations of the paper that reports this interaction (PubMedID 24952347)
0

Data Source:
BioGRID (pull down)

		DNMT3L	NR6A1
Description		DNA methyltransferase 3 like	nuclear receptor subfamily 6 group A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Condensed Nuclear Chromosome Nucleus Cytoplasm Cytosol ESC/E(Z) Complex Catalytic Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Zinc Ion Binding Enzyme Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Zinc Ion Binding Estrogen Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Placenta Development DNA Methylation-dependent Constitutive Heterochromatin Formation Male Meiosis I Spermatogenesis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Epigenetic Programing Of Female Pronucleus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Chorionic Trophoblast Cell Differentiation Genomic Imprinting Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gamete Generation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		DNA methylation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS			Menarche (age at onset) ( 27182965)
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	6 interacting genes: DNMT3L GNB5 NCOA1 NCOR1 NSD1 UIMC1
Entrez ID		29947	2649
HPRD ID		09417	04147
Ensembl ID		ENSG00000142182	ENSG00000148200
Uniprot IDs		Q9UJW3	F1D8S0 F1DAM1 Q15406
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J 7X9D 8TCI 8XEE
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-templated Transcription Positive Regulation Of MiRNA Transcription Cellular Developmental Process	Nuclear Receptor Binding Chromatin Organization Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Chromatin Remodeling Nuclear Thyroid Hormone Receptor Binding Nuclear Estrogen Receptor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose GTPase Activator Complex G-protein Gamma-subunit Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Labyrinthine Layer Morphogenesis Negative Regulation Of RNA Metabolic Process Dark Adaptation Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Cellular Response To Thyroglobulin Triiodothyronine Regulation Of RNA Biosynthetic Process Positive Regulation Of Female Receptivity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Light Adaption Epigenetic Programing Of Female Pronucleus Histone H3K36 Dimethyltransferase Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Thyroglobulin Triiodothyronine Regulation Of Female Receptivity Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Female Mating Behavior Nucleus Carbon Catabolite Regulation Of Transcription Transcription Corepressor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Methylation BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Histone H4K20 Methyltransferase Activity Rhythmic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Heterochromatin Formation Histone H3K36 Methyltransferase Activity Negative Regulation Of Biosynthetic Process Estrous Cycle
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