DNMT3L and NR2E1

Number of citations of the paper that reports this interaction (PubMedID 24952347)
0

Data Source:
BioGRID (pull down)

		DNMT3L	NR2E1
Description		DNA methyltransferase 3 like	nuclear receptor subfamily 2 group E member 1
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GO Annotations	Cellular Component	Heterochromatin Condensed Nuclear Chromosome Nucleus Cytoplasm Cytosol ESC/E(Z) Complex Catalytic Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Enzyme Activator Activity Zinc Ion Binding Enzyme Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Placenta Development DNA Methylation-dependent Constitutive Heterochromatin Formation Male Meiosis I Spermatogenesis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Epigenetic Programing Of Female Pronucleus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Chorionic Trophoblast Cell Differentiation Genomic Imprinting Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Behavioral Fear Response Positive Regulation Of Neuroblast Proliferation Aggressive Behavior Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Neuroblast Proliferation Brain Development Visual Perception Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Anterior Commissure Morphogenesis Cerebral Cortex Development Cell Differentiation Extracellular Matrix Organization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Camera-type Eye Development Negative Regulation Of Apoptotic Process Astrocyte Cell Migration Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Neural Precursor Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		DNA methylation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	6 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RERE
Entrez ID		29947	7101
HPRD ID		09417	07230
Ensembl ID		ENSG00000142182	ENSG00000112333
Uniprot IDs		Q9UJW3	B6ZGT9 Q9Y466
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J 7X9D 8TCI 8XEE	4XAJ
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-templated Transcription Positive Regulation Of MiRNA Transcription Cellular Developmental Process	Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Nuclear Androgen Receptor Binding Regulation Of Chromatin Organization Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Coactivator Activity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-embryonic Development Regulation Of Nucleobase-containing Compound Metabolic Process Cerebellar Purkinje Cell Layer Maturation Chromatin Binding Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Basal Protein Localization Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Epigenetic Programing Of Female Pronucleus ErbB-2 Class Receptor Binding Positive Regulation Of Biosynthetic Process Protein Demethylase Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Histone H3K36 Dimethyltransferase Activity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Branching Morphogenesis Of A Nerve Platelet Dense Granule Membrane Response To Fungicide MRF Binding Guanine Metabolic Process Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Macromolecule Biosynthetic Process Methylation
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