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DNMT3L and GTF2H2
Number of citations of the paper that reports this interaction (PubMedID
24952347
)
0
Data Source:
BioGRID
(pull down)
DNMT3L
GTF2H2
Description
DNA methyltransferase 3 like
general transcription factor IIH subunit 2
Image
GO Annotations
Cellular Component
Heterochromatin
Condensed Nuclear Chromosome
Nucleus
Cytoplasm
Cytosol
ESC/E(Z) Complex
Catalytic Complex
Core TFIIH Complex Portion Of Holo TFIIH Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Nuclear Speck
Molecular Function
Protein Binding
Enzyme Activator Activity
Zinc Ion Binding
Enzyme Binding
Metal Ion Binding
Protein Binding
Zinc Ion Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Metal Ion Binding
Biological Process
Placenta Development
DNA Methylation-dependent Constitutive Heterochromatin Formation
Male Meiosis I
Spermatogenesis
Post-embryonic Development
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Cell Differentiation
Methylation
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Epigenetic Programing Of Female Pronucleus
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of DNA-templated Transcription
Stem Cell Differentiation
Chorionic Trophoblast Cell Differentiation
Genomic Imprinting
Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation
Transposable Element Silencing By Heterochromatin Formation
Autosome Genomic Imprinting
Transposable Element Silencing By PiRNA-mediated DNA Methylation
G Protein-coupled Receptor Internalization
DNA Repair
Nucleotide-excision Repair
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
DNA Damage Response
Response To UV
Pathways
DNA methylation
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS
Interacting Genes
78 interacting genes:
-
ASH2L
ATF1
ATF2
ATF3
ATF4
BLZF1
CDX2
CREB1
CREBL2
CREM
DDIT3
DLX4
DMTF1
DNMT3A
DNMT3B
DR1
E2F3
E2F5
E2F6
EGR1
EGR2
EGR4
ESR1
ESR2
ETS1
F2RL1
FOS
FOSB
FOSL1
FOSL2
GATA1
GMEB1
GSK3B
GTF2H2
GTF2I
GTF3C5
H2AC20
H2BC21
H3C14
H4C14
HAND1
HAND2
HDAC1
HNF4G
HOXA5
HOXC11
ID1
JUN
JUNB
KLF12
LDB1
LHX2
MAFK
MECP2
MED7
MEF2A
MEF2D
NFIL3
NFKB1
NR1H2
NR1I2
NR1I3
NR2E1
NR3C1
NR6A1
NUDT21
PDZD4
PHPT1
RELA
RSL24D1
RXRA
SMAD1
SMAD3
SMAD4
TLE5
TP53
YY1
11 interacting genes:
AR
CDK7
DNMT3L
ERCC2
ERCC3
ERCC8
ERRFI1
GTF2E1
GTF2H1
GTF2H5
SRA1
Entrez ID
29947
2966
HPRD ID
09417
03450
Ensembl ID
ENSG00000142182
ENSG00000145736
Uniprot IDs
Q9UJW3
Q13888
PDB IDs
2PV0
2PVC
2QRV
4U7P
4U7T
5YX2
6BRR
6F57
6KDA
6KDB
6KDL
6KDP
6KDT
6U8P
6U8V
6U8W
6U8X
6U90
6U91
6W89
6W8B
6W8D
6W8J
7X9D
8TCI
8XEE
1Z60
5IVW
5IY6
5IY7
5IY8
5IY9
5O85
5OF4
6NMI
6O9L
6O9M
6RO4
7AD8
7EGB
7EGC
7ENA
7ENC
7LBM
7NVR
7NVW
7NVX
7NVY
7NVZ
7NW0
8BVW
8BYQ
8EBS
8EBT
8EBU
8EBV
8EBW
8EBX
8EBY
8GXQ
8GXS
8WAK
8WAL
8WAN
8WAO
8WAP
8WAQ
8WAR
8WAS
Enriched GO Terms of Interacting Partners
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DNA-binding Transcription Factor Activity
Chromatin
DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Sequence-specific DNA Binding
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Regulator Complex
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
RNA Polymerase II Transcription Regulator Complex
Positive Regulation Of Macromolecule Metabolic Process
Sequence-specific Double-stranded DNA Binding
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Transcription Cis-regulatory Region Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of MiRNA Metabolic Process
Cell Differentiation
Regulation Of MiRNA Transcription
Negative Regulation Of Metabolic Process
Positive Regulation Of MiRNA Metabolic Process
DNA-templated Transcription
Positive Regulation Of MiRNA Transcription
Cellular Developmental Process
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Transcription Initiation At RNA Polymerase II Promoter
DNA-templated Transcription Initiation
Nucleotide-excision Repair
Transcription By RNA Polymerase II
Transcription Factor TFIID Complex
DNA-templated Transcription
DNA-templated Transcription Elongation
Transcription-coupled Nucleotide-excision Repair
DNA Repair
Nucleobase-containing Compound Biosynthetic Process
RNA Metabolic Process
Nucleic Acid Metabolic Process
Macromolecule Biosynthetic Process
CAK-ERCC2 Complex
Hormone-mediated Signaling Pathway
DNA Metabolic Process
Transcription Elongation By RNA Polymerase I
DNA Damage Response
Nucleobase-containing Compound Metabolic Process
UV Protection
Nucleoplasm
Nuclear Receptor-mediated Signaling Pathway
Nucleus
Cellular Response To Stress
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Hair Cell Differentiation
Response To UV
Response To Radiation
Insulin-like Growth Factor Receptor Signaling Pathway
Animal Organ Development
Macromolecule Metabolic Process
DNA Helicase Activity
Cell Death
Maturation Of SSU-rRNA
Programmed Cell Death
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Prostate Induction
Intracellular Receptor Signaling Pathway
Male Somatic Sex Determination
RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity
Response To Stress
Regulation Of Transcription-coupled Nucleotide-excision Repair
Skin Development
Positive Regulation Of Mitotic Recombination
Nucleotide-excision Repair Factor 3 Complex
Male Meiotic Nuclear Division
Nucleotide-excision Repair, Preincision Complex Assembly
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