DNMT3L and ATF2

Number of citations of the paper that reports this interaction (PubMedID 24952347)
0

Data Source:
BioGRID (pull down)

		DNMT3L	ATF2
Description		DNA methyltransferase 3 like	activating transcription factor 2
Image
GO Annotations	Cellular Component	Heterochromatin Condensed Nuclear Chromosome Nucleus Cytoplasm Cytosol ESC/E(Z) Complex Catalytic Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Site Of Double-strand Break RNA Polymerase II Transcription Regulator Complex H4 Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Zinc Ion Binding Enzyme Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding Sequence-specific DNA Binding Histone H2B Acetyltransferase Activity Metal Ion Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Placenta Development DNA Methylation-dependent Constitutive Heterochromatin Formation Male Meiosis I Spermatogenesis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Methylation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Epigenetic Programing Of Female Pronucleus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Chorionic Trophoblast Cell Differentiation Genomic Imprinting Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development NK T Cell Differentiation Liver Development Hematopoietic Progenitor Cell Differentiation Outflow Tract Morphogenesis Brainstem Development Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Lipid Metabolic Process Apoptotic Process Response To Osmotic Stress DNA Damage Response Vacuole Organization JNK Cascade Heart Development Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-threonine Phosphorylation Abducens Nucleus Development Hypoglossal Nucleus Development Facial Nucleus Development BMP Signaling Pathway Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Oxidative Stress P38MAPK Cascade MRNA Transcription By RNA Polymerase II Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Neurofilament Cytoskeleton Organization Detection Of Cell Density Adipose Tissue Development Cellular Response To Anisomycin Motor Neuron Apoptotic Process Hepatocyte Apoptotic Process Cellular Response To Virus Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Development Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Cellular Response To Leucine Starvation
Pathways		DNA methylation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Pseudoephedrine
Diseases
GWAS			Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	61 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FAM13A-AS1 FOS GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I USP14 UTF1 XPO1 YY1
Entrez ID		29947	1386
HPRD ID		09417	00443
Ensembl ID		ENSG00000142182	ENSG00000115966
Uniprot IDs		Q9UJW3	A4D7V5 P15336
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J 7X9D 8TCI 8XEE	1BHI 1T2K 4H36 6ZQS 6ZR5
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process DNA-templated Transcription Positive Regulation Of MiRNA Transcription Cellular Developmental Process	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Intracellular Signaling Cassette Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity DNA Binding Response To Stress Transcription Cis-regulatory Region Binding Integrated Stress Response Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity MAPK Cascade RNA Polymerase II-specific DNA-binding Transcription Factor Binding Macromolecule Metabolic Process DNA Damage Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Senescence Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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