ELK1 and EMX1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ELK1	EMX1
Gene Name		ELK1, member of ETS oncogene family	empty spiracles homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Dendrite Neuronal Cell Body Axon Terminus	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Protein Binding Sequence-specific DNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Response To Light Stimulus Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Cellular Response To Testosterone Stimulus Cellular Response To Gamma Radiation Positive Regulation Of Neuron Death	In Utero Embryonic Development Regulation Of Transcription, DNA-templated Post-embryonic Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Response To Drug Brain Morphogenesis Neuron Projection Extension
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: APP BRCA1 CDK6 CEBPB CREBBP EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 PIAS2 SNCA SRF STARD3NL STK16 TAOK2 UBC UBE2I	7 interactors: ALX4 ELK1 GTF2A1L HOXA10 POLR2D PRDM4 TP63
Entrez ID		2002	2016
HPRD ID		02407	08963
Ensembl ID		ENSG00000126767	ENSG00000135638
Uniprot IDs		P19419 Q86SR6	Q04741
PDB IDs		1DUX
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Toll-like Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Response To Growth Factor Innate Immune Response Response To Stress Immune System Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Innate Immune Response Cellular Response To Organic Substance Transcription, DNA-templated Immune Response Regulation Of Phosphorylation RNA Biosynthetic Process	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Embryonic Limb Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Limb Morphogenesis Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Limb Development Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Proximal/distal Pattern Formation Response To Gamma Radiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Pattern Specification Process Positive Regulation Of Transcription, DNA-templated Ectoderm And Mesoderm Interaction Epidermal Cell Division Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Regulation Of Metabolic Process Hair Follicle Development Hair Cycle Process Skeletal System Development Hair Cycle Cellular Response To Testosterone Stimulus Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development MRNA Export From Nucleus In Response To Heat Stress Embryonic Morphogenesis Digestive Tract Development Cellular Response To Radiation Response To Ionizing Radiation Digestive System Development Regulation Of Epidermal Cell Division Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process
Tagcloud ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular	124a accumulate annually appearing authentic cancers defect discontinued endoscopic endoscopy endpoint enrolled enrolment epigenetic excluding field gastric helicobacter metachronous multicentre nkx6 planned preselected pylori quartile takes trends undergone univariate
Tagcloud (Difference) ?		activate activated atf2 hearts hypertrophic ischemia jnk jun kd mapk mapkapk2 mapks mekk1 myocyte myocytes perfused reactivating reperfusion rk sapks sek1 speculate stimulates stresses subfamily superfamily transactivating transfection ventricular	124a accumulate annually appearing authentic cancers defect discontinued endoscopic endoscopy endpoint enrolled enrolment epigenetic excluding field gastric helicobacter metachronous multicentre nkx6 planned preselected pylori quartile takes trends undergone univariate
Tagcloud (Intersection) ?