GAPDH and SMN1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GAPDH	SMN1
Gene Name		glyceraldehyde-3-phosphate dehydrogenase	survival of motor neuron 1, telomeric
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Ribonucleoprotein Complex Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome GAIT Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Negative Regulation Of Translation Peptidyl-cysteine S-trans-nitrosylation Small Molecule Metabolic Process Protein Stabilization Neuron Apoptotic Process Oxidation-reduction Process Cellular Response To Interferon-gamma	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	snRNP Assembly Metabolism of non-coding RNA
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
Diseases
GWAS
Protein-Protein Interactions		75 interactors: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FKBP6 GADD45A GAS7 GOT2 GRM1 GSK3B HES1 HNF4G HTT KARS KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ	136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		2597	6606
HPRD ID		00713	02646
Ensembl ID		ENSG00000111640	ENSG00000172062
Uniprot IDs		P04406	B4DP61 Q16637
PDB IDs		1U8F 1ZNQ 2FEH 3GPD	1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death System Development Response To Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Process Multicellular Organismal Development Response To Abiotic Stimulus Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Organelle Organization Neuron Apoptotic Process Cell Cycle Cellular Response To Stress Regulation Of Catalytic Activity Neuron Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Cellular Response To Heat Negative Regulation Of Transferase Activity Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Homeostatic Process Positive Regulation Of Intracellular Transport Cell Differentiation Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process
Tagcloud ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Difference) ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Intersection) ?