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SMN1 and WDR73
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
SMN1
WDR73
Gene Name
survival of motor neuron 1, telomeric
WD repeat domain 73
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Cytosol
Cajal Body
Z Disc
SMN Complex
SMN-Sm Protein Complex
Gemini Of Coiled Bodies
Molecular Function
RNA Binding
Protein Binding
Identical Protein Binding
Biological Process
Spliceosomal Complex Assembly
Spliceosomal SnRNP Assembly
Nervous System Development
Gene Expression
NcRNA Metabolic Process
Pathways
snRNP Assembly
Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
136 interactors:
A1BG
A2M
ACTB
ACTL6B
ADAMTS10
AGAP1
APLP1
ARFGAP1
ATP5B
ATP6V1A
BAG6
BCL2
C19orf60
CARHSP1
CCDC90B
CENPB
COIL
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CSAD
DDAH2
DDX20
DHX9
DMPK
DOCK7
DUS2
DYNC1I1
EEF1A1
EIF3G
EXT2
EZH2
FAM20C
FBL
FGB
FLAD1
FUBP1
GAPDH
GAR1
GDF9
GEMIN2
GEMIN5
GEMIN7
HADHB
HIST3H3
HMGXB3
HNRNPR
HNRNPU
HNRNPUL1
IGHM
ILF3
IMMT
INPP5K
JADE1
KDM1A
KIF5A
KLHL5
KMT2B
KPNB1
LENG8
LRIF1
LSM1
LSM10
LSM11
LSM2
LSM3
LSM4
LSM5
LSM6
LSM7
MAST2
MED31
MKI67
MPP1
MRPL37
MSH2
NGFR
NKIRAS2
NMT2
OSTF1
PDE4DIP
PKM
PLXNA3
POLR2A
POP7
PSME1
QARS
RBBP4
RBBP6
RBFOX2
RBM48
RN7SL1
RNU1-1
RNU2-1
RPL13
RPS2
RXRA
SDF4
SEMA5B
SETDB1
SMC5
SMN2
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNUPN
SP110
STRAP
STXBP2
STXBP3
SULT1A3
SUMO3
SYNCRIP
TAF1C
TIAL1
TLE1
TMSB4X
TP53
TRMT2A
TUBA1A
TUBB3
UCHL1
UNC119
USP4
WDR18
WDR73
WDYHV1
WIZ
ZBTB16
ZNF431
ZRANB2
ZXDC
7 interactors:
ANXA7
CDKN1A
DAZAP2
SMN1
TK1
TNFRSF14
TSC22D1
Entrez ID
6606
84942
HPRD ID
02646
08608
Ensembl ID
ENSG00000172062
ENSG00000177082
Uniprot IDs
B4DP61
Q16637
Q6P4I2
PDB IDs
1G5V
1MHN
2LEH
3S6N
4A4E
4A4G
4GLI
Enriched GO Terms of Interacting Partners
?
MRNA Processing
RNA Splicing
MRNA Metabolic Process
RNA Processing
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
RNA Metabolic Process
Spliceosomal SnRNP Assembly
Nucleobase-containing Compound Metabolic Process
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Heterocycle Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Ribonucleoprotein Complex Assembly
Ribonucleoprotein Complex Biogenesis
NcRNA Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Cellular Macromolecular Complex Assembly
Histone MRNA Metabolic Process
Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Cellular Process
Nuclear-transcribed MRNA Catabolic Process
Posttranscriptional Regulation Of Gene Expression
Cellular Component Assembly
MRNA Catabolic Process
RNA Catabolic Process
CRD-mediated MRNA Stabilization
Regulation Of Protein Metabolic Process
Termination Of RNA Polymerase II Transcription
Regulation Of Cellular Protein Metabolic Process
DNA-templated Transcription, Termination
RNA Biosynthetic Process
MRNA 3'-end Processing
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Transcription, DNA-templated
RNA 3'-end Processing
Regulation Of Mitotic Cell Cycle Phase Transition
Spliceosomal Complex Assembly
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle Phase Transition
Developmental Process
Regulation Of Metabolic Process
Cellular Macromolecule Catabolic Process
Cell Differentiation
Catabolic Process
Fetal Process Involved In Parturition
Skeletal Muscle Cell Proliferation
Digestive Tract Development
Digestive System Development
Response To Glucocorticoid
Response To Corticosteroid
Response To Toxic Substance
Response To Organic Cyclic Compound
Positive Regulation Of Cytokine Secretion Involved In Immune Response
Intestinal Epithelial Cell Maturation
Response To Cortisol
Thymidine Metabolic Process
Response To Organic Substance
Cellular Response To UV-B
Negative Regulation Of Alpha-beta T Cell Proliferation
Deoxyribonucleoside Monophosphate Biosynthetic Process
Positive Regulation Of Cell Activation
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Stress-induced Premature Senescence
Response To Metal Ion
Regulation Of Cytokine Secretion Involved In Immune Response
Cellular Water Homeostasis
Regulation Of Lymphocyte Activation
Mitotic Cell Cycle Arrest
Regulation Of Cell Proliferation
Response To UV-B
Positive Regulation Of T Cell Migration
Intestinal Epithelial Cell Development
Parturition
Regulation Of Protein Import Into Nucleus, Translocation
Regulation Of T Cell Migration
Intestinal Epithelial Cell Differentiation
Response To Extracellular Stimulus
Epithelial Cell Maturation
Regulation Of Cell Activation
Response To Inorganic Substance
Response To Steroid Hormone
Negative Regulation Of Alpha-beta T Cell Activation
Response To Copper Ion
Tagcloud
?
atrophy
centromeric
compensate
copies
copy
degeneration
deletions
detectable
display
donor
easily
exon
fails
fatal
harbor
hindering
homozygous
infant
intragenic
italian
modifier
muscular
null
predictable
sma
smn2
splice
unusually
weakness
Tagcloud (Difference)
?
atrophy
centromeric
compensate
copies
copy
degeneration
deletions
detectable
display
donor
easily
exon
fails
fatal
harbor
hindering
homozygous
infant
intragenic
italian
modifier
muscular
null
predictable
sma
smn2
splice
unusually
weakness
Tagcloud (Intersection)
?