GAPDH and USP25

Number of citations of the paper that reports this interaction (PMID 16501887)
5

Data Source:
BioGRID (two hybrid)

		GAPDH	USP25
Gene Name		glyceraldehyde-3-phosphate dehydrogenase	ubiquitin specific peptidase 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Ribonucleoprotein Complex Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome GAIT Complex	Nucleus Cytoplasm
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity SUMO Binding
	Biological Process	Microtubule Cytoskeleton Organization Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Negative Regulation Of Translation Peptidyl-cysteine S-trans-nitrosylation Small Molecule Metabolic Process Protein Stabilization Neuron Apoptotic Process Oxidation-reduction Process Cellular Response To Interferon-gamma	Cellular Protein Modification Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
Diseases
GWAS			Panic disorder ( 19165232) Parkinson's disease ( 21738487)
Protein-Protein Interactions		75 interactors: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FKBP6 GADD45A GAS7 GOT2 GRM1 GSK3B HES1 HNF4G HTT KARS KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ	14 interactors: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SYK UBC UBE2I ZNF426
Entrez ID		2597	29761
HPRD ID		00713	05296
Ensembl ID		ENSG00000111640	ENSG00000155313
Uniprot IDs		P04406	Q9UHP3
PDB IDs		1U8F 1ZNQ 2FEH 3GPD
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Cell Death Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death System Development Response To Stimulus Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Establishment Of Protein Localization Positive Regulation Of Apoptotic Process Multicellular Organismal Development Response To Abiotic Stimulus Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Organelle Organization Neuron Apoptotic Process Cell Cycle Cellular Response To Stress Regulation Of Catalytic Activity Neuron Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Cellular Response To Heat Negative Regulation Of Transferase Activity Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Homeostatic Process Positive Regulation Of Intracellular Transport Cell Differentiation Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition	Protein Sumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Peptidyl-amino Acid Modification Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Cytokine Regulation Of Cellular Protein Metabolic Process Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interferon-gamma Positive Regulation Of Cellular Protein Catabolic Process Response To Interferon-gamma Response To Organic Substance Viral Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Muscle Fiber Development Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Defense Response Negative Regulation Of Biosynthetic Process Immune System Process Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of SUMO Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Metabolic Process JNK Cascade Skeletal Muscle Fiber Adaptation Beta Selection Positive Regulation Of Interleukin-3 Biosynthetic Process Cellular Response To Molecule Of Fungal Origin Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	chains cleaved cys178 cysteine deubiquitinated deubiquitinating deubiquitination dub emerged his607 histidine ifn interferon irf3 lost lysine mechanistically polyubiquitin potentiated proteases residue rig screen traf2 traf6 triggered tumornecrosis ubiquitination usps
Tagcloud (Difference) ?		apart caenorhabditis cloning cyst drive elegans ends flanking frame genetics globodera gluconeogenesis glyceraldehyde glycolysis gonads gpd green leader microinjected nematode nucleotides obligatory parasitic pathogenicity potato rostochiensis sl1 spliced	chains cleaved cys178 cysteine deubiquitinated deubiquitinating deubiquitination dub emerged his607 histidine ifn interferon irf3 lost lysine mechanistically polyubiquitin potentiated proteases residue rig screen traf2 traf6 triggered tumornecrosis ubiquitination usps
Tagcloud (Intersection) ?