SMN1 and KIF5A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMN1	KIF5A
Gene Name		survival of motor neuron 1, telomeric	kinesin family member 5A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Cytosol Kinesin Complex Microtubule Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process	Microtubule-based Movement Synaptic Transmission Axon Guidance Blood Coagulation Protein Localization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Intracellular Transport
Pathways		snRNP Assembly Metabolism of non-coding RNA	Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS			Rheumatoid arthritis ( 18794853)
Protein-Protein Interactions		136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	16 interactors: DTNB EXOC1 ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 NCOA2 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TSG101 YAP1
Entrez ID		6606	3798
HPRD ID		02646	09108
Ensembl ID		ENSG00000172062	ENSG00000155980
Uniprot IDs		B4DP61 Q16637	J3KNA1 Q12840
PDB IDs		1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process	System Development Cytoskeleton-dependent Intracellular Transport Multicellular Organismal Development Anatomical Structure Development Regulation Of Signaling Nervous System Development Cellular Localization Developmental Process Regulation Of Potassium Ion Transport Fetal Process Involved In Parturition Regulation Of Signal Transduction Establishment Of Localization In Cell Microtubule-based Movement Negative Regulation Of Melanin Biosynthetic Process Skeletal Muscle Cell Proliferation Stress Granule Disassembly Neuron Projection Development Keratinocyte Differentiation Movement Of Cell Or Subcellular Component Axon Guidance Brain-derived Neurotrophic Factor Receptor Signaling Pathway Generation Of Neurons Positive Regulation Of Ras GTPase Activity Neuron Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Neuron Projection Development Cell Differentiation Neurogenesis Positive Regulation Of CAMP-dependent Protein Kinase Activity Microtubule-based Transport Epidermal Cell Differentiation Cell Morphogenesis Negative Regulation Of Cell Projection Organization Regulation Of Extracellular Vesicular Exosome Assembly Plus-end-directed Vesicle Transport Along Microtubule Response To Cortisol Thymidine Metabolic Process Response To Ionizing Radiation Cell Development Axonogenesis Regulation Of Ras GTPase Activity Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Epithelial Cell Differentiation Neuron Differentiation Intracellular Signal Transduction Cell Projection Organization Deoxyribonucleoside Monophosphate Biosynthetic Process Response To CGMP
Tagcloud ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	adaptor autonomous axonal cargo charcot cmt contexts degenerate exacerbates hsp hyperexcitability incompletely kbp kif1b kifs kinesin marie motors nonmitochondrial paraplegia polyneuropathy redundant redundantly reminiscent spastic strikingly vertebrate
Tagcloud (Difference) ?		atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness	adaptor autonomous axonal cargo charcot cmt contexts degenerate exacerbates hsp hyperexcitability incompletely kbp kif1b kifs kinesin marie motors nonmitochondrial paraplegia polyneuropathy redundant redundantly reminiscent spastic strikingly vertebrate
Tagcloud (Intersection) ?