GAPDH and CAMK1

Number of citations of the paper that reports this interaction (PubMedID 15680915)
0

Data Source:
HPRD (in vitro, in vivo)

		GAPDH	CAMK1
Description		glyceraldehyde-3-phosphate dehydrogenase	calcium/calmodulin dependent protein kinase I
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome GAIT Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Postsynaptic Density
	Molecular Function	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Aspartic-type Endopeptidase Inhibitor Activity Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding Disordered Domain Specific Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine Production Immune System Process Glucose Metabolic Process Glycolytic Process Regulation Of Translation Apoptotic Process Negative Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Negative Regulation Of Translation Killing Of Cells Of Another Organism Positive Regulation Of Type I Interferon Production Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Defense Response To Fungus Neuron Apoptotic Process Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Type II Interferon	Protein Phosphorylation Nucleocytoplasmic Transport Signal Transduction Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Intracellular Signal Transduction Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Glycolysis Gluconeogenesis	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol	Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		92 interacting genes: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CEBPA CHP1 DUX4 DYNLL1 EGFR ERBB2 FBXO7 FKBP6 FOXP1 GADD45A GAS7 GOT2 GRIA2 GRM1 HES1 HNF4G HSPB2 HTT ITGB5 KARS1 KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 LINC01554 MAPK1 MTNR1A MYOC NFYC NR1H4 NUFIP2 OGT OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 PTPRF RAB2A RBM5 RPA2 RXFP4 S100A6 SERPINB9 SHANK3 SIAH1 SIRT1 SLC2A1 SLC2A4 SMARCA2 SMN1 SUMO4 TERF1 TINF2 TK1 TPPP TSC2 TXNIP USP25 WEE2-AS1 YWHAE YWHAQ	23 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 HUNK IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		2597	8536
HPRD ID		00713	05412
Ensembl ID		ENSG00000111640	ENSG00000134072
Uniprot IDs		P04406 V9HVZ4	B0YIY3 Q14012
PDB IDs		1U8F 1ZNQ 3GPD 4WNC 4WNI 6ADE 6IQ6 6M61 6YND 6YNE 6YNF 6YNH 8DNS 8G12 8G13 8G14 8G15 8G16 8G17 8P5F	4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?		Developmental Process Cellular Developmental Process Nucleus Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Shelterin Complex Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nuclear Telomere Cap Complex Protein-containing Complex Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Cellular Response To Stress Regulation Of Multicellular Organismal Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Capping Regulation Of Phosphorylation Nucleoplasm Regulation Of Developmental Process Negative Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Assembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Programmed Cell Death Positive Regulation Of Signaling Positive Regulation Of Chromosome Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Development Positive Regulation Of Cellular Component Organization System Development	Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cyclin D1-CDK4 Complex Cell Cycle Phase Transition Response To Metal Ion Peptidyl-cysteine S-nitrosylase Activity Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Activity Positive Regulation Of Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Calcium-mediated Signaling Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Autophagy Positive Regulation Of Interleukin-1 Production Kinase Activity Regulation Of Metabolic Process Calcium-dependent Protein Binding Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Response To Lead Ion Calyx Of Held Regulation Of Neurotransmitter Uptake Regulation Of Cell Cycle Process Regulation Of Neuron Apoptotic Process Regulation Of Locomotion Nucleus Regulation Of Cell Cycle Calcium/calmodulin-dependent Protein Kinase Activity Protein-containing Complex Regulation Of Interleukin-1 Production Nucleoplasm Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Mitotic Cell Cycle
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