SMN1 and SNUPN

Number of citations of the paper that reports this interaction (PubMedID 12095920)
66

Data Source:
BioGRID (pull down)

		SMN1	SNUPN
Description		survival of motor neuron 1, telomeric	snurportin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Plasma Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Cap Binding RNA Binding Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing	RNA Import Into Nucleus Protein Import Into Nucleus Cytoskeleton Organization Protein Complex Oligomerization Protein Tetramerization SnRNA Import Into Nucleus
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	snRNP Assembly
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	15 interacting genes: DBN1 DDX20 ENO2 GCNT3 KPNB1 MEX3B PAFAH1B2 PEX5 RNF126 RPL17 SMN1 SNRPB TNNT3 XPO1 ZPR1
Entrez ID		6606	10073
HPRD ID		02646	07441
Ensembl ID		ENSG00000172062	ENSG00000169371
Uniprot IDs		B4DP61 E7EQZ4 Q16637	O95149
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30	1XK5 2P8Q 2Q5D 2QNA 3GB8 3GJX 3LWW 3NBY 3NBZ 3NC0 5DIS
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding	Gemini Of Cajal Bodies SMN-Sm Protein Complex Growth Cone Spliceosomal SnRNP Assembly Cajal Body SMN Complex Cytoplasm Regulation Of Nucleocytoplasmic Transport Cerebral Cortex Neuron Differentiation Perikaryon Regulation Of Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway RNA Splicing Cerebral Cortex Cell Migration Cytosol Negative Regulation Of ERBB Signaling Pathway Cell Cortex Positive Regulation Of Dendritic Spine Development Protein-containing Complex Forebrain Neuron Differentiation Positive Regulation Of Protein Import Into Nucleus MRNA Processing Telencephalon Cell Migration Forebrain Cell Migration Negative Regulation Of Core Promoter Binding Spliceosomal Complex Assembly Protein-RNA Complex Assembly Positive Regulation Of Calcium-dependent ATPase Activity DNA Endoreduplication Pre-mRNA Catabolic Process Acetylgalactosaminyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity Regulation Of Dendritic Spine Development Protein Domain Specific Binding Protein Monoubiquitination Cell Communication By Chemical Coupling Synaptic Membrane RNA Binding Nuclear Membrane Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding U2 SnRNP Binding Cellular Response To Triglyceride N-acetyllactosaminide Beta-1,6-N-acetylglucosaminyltransferase Activity Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity
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